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A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.

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Title: A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.
Authors: Zhang P; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Narayanan E; Moderna Inc., Cambridge, MA, USA., Liu Q; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Tsybovsky Y; Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Boswell K; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Ding S; Université de Montreal, Montreal, Quebec, Canada., Hu Z; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA., Follmann D; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA., Lin Y; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Miao H; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Schmeisser H; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Rogers D; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Falcone S; Moderna Inc., Cambridge, MA, USA., Elbashir SM; Moderna Inc., Cambridge, MA, USA., Presnyak V; Moderna Inc., Cambridge, MA, USA., Bahl K; Moderna Inc., Cambridge, MA, USA., Prabhakaran M; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Chen X; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Sarfo EK; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Ambrozak DR; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Gautam R; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA., Martin MA; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA., Swerczek J; Experimental Primate Virology Section, NIAID, Poolesville, MD, USA., Herbert R; Experimental Primate Virology Section, NIAID, Poolesville, MD, USA., Weiss D; Bioqual Inc., Rockville, MD, USA., Misamore J; Bioqual Inc., Rockville, MD, USA., Ciaramella G; Moderna Inc., Cambridge, MA, USA., Himansu S; Moderna Inc., Cambridge, MA, USA., Stewart-Jones G; Moderna Inc., Cambridge, MA, USA., McDermott A; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Koup RA; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Mascola JR; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Finzi A; Université de Montreal, Montreal, Quebec, Canada., Carfi A; Moderna Inc., Cambridge, MA, USA., Fauci AS; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA., Lusso P; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA. plusso@niaid.nih.gov.
Source: Nature medicine [Nat Med] 2021 Dec; Vol. 27 (12), pp. 2234-2245. Date of Electronic Publication: 2021 Dec 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Narayanan+E%22">Narayanan E</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tsybovsky+Y%22">Tsybovsky Y</searchLink>; Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Boswell+K%22">Boswell K</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ding+S%22">Ding S</searchLink>; Université de Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Follmann+D%22">Follmann D</searchLink>; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Miao+H%22">Miao H</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schmeisser+H%22">Schmeisser H</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+D%22">Rogers D</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Falcone+S%22">Falcone S</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Elbashir+SM%22">Elbashir SM</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Presnyak+V%22">Presnyak V</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bahl+K%22">Bahl K</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Prabhakaran+M%22">Prabhakaran M</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sarfo+EK%22">Sarfo EK</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ambrozak+DR%22">Ambrozak DR</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gautam+R%22">Gautam R</searchLink>; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Martin+MA%22">Martin MA</searchLink>; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Swerczek+J%22">Swerczek J</searchLink>; Experimental Primate Virology Section, NIAID, Poolesville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Herbert+R%22">Herbert R</searchLink>; Experimental Primate Virology Section, NIAID, Poolesville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+D%22">Weiss D</searchLink>; Bioqual Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Misamore+J%22">Misamore J</searchLink>; Bioqual Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ciaramella+G%22">Ciaramella G</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Himansu+S%22">Himansu S</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stewart-Jones+G%22">Stewart-Jones G</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22McDermott+A%22">McDermott A</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Koup+RA%22">Koup RA</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mascola+JR%22">Mascola JR</searchLink>; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Finzi+A%22">Finzi A</searchLink>; Université de Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Carfi+A%22">Carfi A</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fauci+AS%22">Fauci AS</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lusso+P%22">Lusso P</searchLink>; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA. plusso@niaid.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2021 Dec; Vol. 27 (12), pp. 2234-2245. <i>Date of Electronic Publication: </i>2021 Dec 09.
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