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TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.

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Title: TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.
Authors: Shakiba M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY., Zumbo P; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY., Espinosa-Carrasco G; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Menocal L; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Dündar F; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY., Carson SE; Department of Biochemistry, Cell and Molecular Biology, Weill Cornell Medicine, New York, NY., Bruno EM; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Sanchez-Rivera FJ; Cancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Lowe SW; Cancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Camara S; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY., Reuter VP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY., Socci ND; Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY., Whitlock B; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Tamzalit F; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Huse M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY., Hellmann MD; Parker Institute for Cancer Immunotherapy, San Francisco, CA.; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Weill Cornell Medical College, Cornell University, New York, NY., Wells DK; Parker Institute for Cancer Immunotherapy, San Francisco, CA., Defranoux NA; Parker Institute for Cancer Immunotherapy, San Francisco, CA., Betel D; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY., Philip M; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN., Schietinger A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY.
Source: The Journal of experimental medicine [J Exp Med] 2022 Feb 07; Vol. 219 (2). Date of Electronic Publication: 2021 Dec 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.
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  Data: <searchLink fieldCode="AU" term="%22Shakiba+M%22">Shakiba M</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Zumbo+P%22">Zumbo P</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Espinosa-Carrasco+G%22">Espinosa-Carrasco G</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Menocal+L%22">Menocal L</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Dündar+F%22">Dündar F</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Carson+SE%22">Carson SE</searchLink>; Department of Biochemistry, Cell and Molecular Biology, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Bruno+EM%22">Bruno EM</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Sanchez-Rivera+FJ%22">Sanchez-Rivera FJ</searchLink>; Cancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Camara+S%22">Camara S</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Koche+RP%22">Koche RP</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Reuter+VP%22">Reuter VP</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Socci+ND%22">Socci ND</searchLink>; Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Whitlock+B%22">Whitlock B</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Tamzalit+F%22">Tamzalit F</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Huse+M%22">Huse M</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY.<br /><searchLink fieldCode="AU" term="%22Hellmann+MD%22">Hellmann MD</searchLink>; Parker Institute for Cancer Immunotherapy, San Francisco, CA.; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Weill Cornell Medical College, Cornell University, New York, NY.<br /><searchLink fieldCode="AU" term="%22Wells+DK%22">Wells DK</searchLink>; Parker Institute for Cancer Immunotherapy, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Defranoux+NA%22">Defranoux NA</searchLink>; Parker Institute for Cancer Immunotherapy, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Betel+D%22">Betel D</searchLink>; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Philip+M%22">Philip M</searchLink>; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Schietinger+A%22">Schietinger A</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2022 Feb 07; Vol. 219 (2). <i>Date of Electronic Publication: </i>2021 Dec 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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