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Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target.

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Title: Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target.
Authors: Kroenke MA; Clinical Immunology, Translational Medicine, Amgen, Thousand Oaks, CA, United States., Barger TE; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States., Hu J; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States., Miller MJ; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States., Kalenian K; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States., He L; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States., Hsu H; Inflammation Research, Amgen, Thousand Oaks, CA, United States., Bartley Y; Global Safety, Amgen, Thousand Oaks, CA, United States., Chow VF; Clinical Pharmacology, Modeling and Simulation, Translational Medicine, Amgen, Thousand Oaks, CA, United States., Teixeira Dos Santos MC; Clinical Biomarkers and Diagnostics, Translational Medicine, Amgen, Thousand Oaks, CA, United States., Sullivan BA; Clinical Biomarkers and Diagnostics, Translational Medicine, Amgen, Thousand Oaks, CA, United States., Cheng LE; Early Development, Translational Medicine, Amgen, Thousand Oaks, CA, United States., Parnes JR; Early Development, Translational Medicine, Amgen, Thousand Oaks, CA, United States., Padaki R; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States., Kuhns S; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States., Mytych DT; Clinical Immunology, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
Source: Frontiers in immunology [Front Immunol] 2021 Dec 14; Vol. 12, pp. 782788. Date of Electronic Publication: 2021 Dec 14 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target.
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  Data: <searchLink fieldCode="AU" term="%22Kroenke+MA%22">Kroenke MA</searchLink>; Clinical Immunology, Translational Medicine, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Barger+TE%22">Barger TE</searchLink>; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Miller+MJ%22">Miller MJ</searchLink>; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Kalenian+K%22">Kalenian K</searchLink>; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Hsu+H%22">Hsu H</searchLink>; Inflammation Research, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Bartley+Y%22">Bartley Y</searchLink>; Global Safety, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Chow+VF%22">Chow VF</searchLink>; Clinical Pharmacology, Modeling and Simulation, Translational Medicine, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Teixeira+Dos+Santos+MC%22">Teixeira Dos Santos MC</searchLink>; Clinical Biomarkers and Diagnostics, Translational Medicine, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Sullivan+BA%22">Sullivan BA</searchLink>; Clinical Biomarkers and Diagnostics, Translational Medicine, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Cheng+LE%22">Cheng LE</searchLink>; Early Development, Translational Medicine, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Parnes+JR%22">Parnes JR</searchLink>; Early Development, Translational Medicine, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Padaki+R%22">Padaki R</searchLink>; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Kuhns+S%22">Kuhns S</searchLink>; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.<br /><searchLink fieldCode="AU" term="%22Mytych+DT%22">Mytych DT</searchLink>; Clinical Immunology, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
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              Text: 2021 Dec 14
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