Bone-Targeted Bortezomib Inhibits Bortezomib-Resistant Multiple Myeloma in Mice by Providing Higher Levels of Bortezomib in Bone.

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Title: Bone-Targeted Bortezomib Inhibits Bortezomib-Resistant Multiple Myeloma in Mice by Providing Higher Levels of Bortezomib in Bone.
Authors: Tao J; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Srinivasan V; Department of Chemistry, University of Rochester, Rochester, NY, USA., Yi X; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Zhao Y; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Zhang H; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Lin X; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Zhou X; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Boyce BF; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA., Villalta PW; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Ebetino FH; Department of Chemistry, University of Rochester, Rochester, NY, USA.; BioVinc, Pasadena, CA, USA., Ho KK; Ionova Life Science Co., Ltd, Shenzhen, China., Boeckman RK Jr; Department of Chemistry, University of Rochester, Rochester, NY, USA., Xing L; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Source: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2022 Apr; Vol. 37 (4), pp. 629-642. Date of Electronic Publication: 2022 Jan 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8610640 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-4681 (Electronic) Linking ISSN: 08840431 NLM ISO Abbreviation: J Bone Miner Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1523-4681
DOI:10.1002/jbmr.4496