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Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice.

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Title: Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice.
Authors: Hioe CE; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; James J. Peters VA Medical Center, Bronx, New York, New York, United States of America., Li G; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America., Liu X; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Tsahouridis O; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America., He X; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Funaki M; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Klingler J; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; James J. Peters VA Medical Center, Bronx, New York, New York, United States of America., Tang AF; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; School of Medicine, University of California, San Francisco, California, United States of America., Feyznezhad R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Heindel DW; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Wang XH; VA New York Harbor Healthcare System-Manhattan, New York, New York, United States of America., Spencer DA; Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America., Hu G; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Satija N; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Prévost J; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Finzi A; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Hessell AJ; Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America., Wang S; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Lu S; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Chen BK; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Zolla-Pazner S; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Upadhyay C; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Alvarez R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Su L; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, Departments of Pharmacology and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2022 Jan 05; Vol. 18 (1), pp. e1010183. Date of Electronic Publication: 2022 Jan 05 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice.
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  Data: <searchLink fieldCode="AU" term="%22Hioe+CE%22">Hioe CE</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; James J. Peters VA Medical Center, Bronx, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Tsahouridis+O%22">Tsahouridis O</searchLink>; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Funaki+M%22">Funaki M</searchLink>; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Klingler+J%22">Klingler J</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; James J. Peters VA Medical Center, Bronx, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Tang+AF%22">Tang AF</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; School of Medicine, University of California, San Francisco, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Feyznezhad+R%22">Feyznezhad R</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Heindel+DW%22">Heindel DW</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+XH%22">Wang XH</searchLink>; VA New York Harbor Healthcare System-Manhattan, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Spencer+DA%22">Spencer DA</searchLink>; Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.<br /><searchLink fieldCode="AU" term="%22Hu+G%22">Hu G</searchLink>; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Satija+N%22">Satija N</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Prévost+J%22">Prévost J</searchLink>; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Finzi+A%22">Finzi A</searchLink>; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Hessell+AJ%22">Hessell AJ</searchLink>; Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Chen+BK%22">Chen BK</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Zolla-Pazner+S%22">Zolla-Pazner S</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Upadhyay+C%22">Upadhyay C</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Alvarez+R%22">Alvarez R</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Su+L%22">Su L</searchLink>; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, Departments of Pharmacology and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2022 Jan 05; Vol. 18 (1), pp. e1010183. <i>Date of Electronic Publication: </i>2022 Jan 05 (<i>Print Publication: </i>2022).
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