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Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study.

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Title: Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study.
Authors: Costa Clemens SA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Institute of Global Health, University of Siena, Siena, Italy., Weckx L; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil., Clemens R; International Vaccine Institute, Seoul, Korea., Almeida Mendes AV; Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil., Ramos Souza A; Universidade Federal de São Paulo, São Paulo, Brazil., Silveira MBV; Universidade Federal de São Paulo, São Paulo, Brazil., da Guarda SNF; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil; Department of Pediatrics, Universidade Federal da Bahia, Salvador, Brazil., de Nobrega MM; Universidade Federal de São Paulo, São Paulo, Brazil., de Moraes Pinto MI; Universidade Federal de São Paulo, São Paulo, Brazil., Gonzalez IGS; Universidade Federal de São Paulo, São Paulo, Brazil., Salvador N; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil., Franco MM; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil., de Avila Mendonça RN; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil., Queiroz Oliveira IS; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil., de Freitas Souza BS; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil; Gonçalo Moniz Institute, Fiocruz, Salvador, Brazil., Fraga M; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil., Aley P; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Cantrell L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Dejnirattisai W; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Mongkolsapaya J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Supasa P; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Screaton GR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK., Lambe T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK., Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Pollard AJ; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: andrew.pollard@paediatrics.ox.ac.uk.
Corporate Authors: RHH-001 study team
Source: Lancet (London, England) [Lancet] 2022 Feb 05; Vol. 399 (10324), pp. 521-529. Date of Electronic Publication: 2022 Jan 21.
Publication Type: Clinical Trial, Phase IV; Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study.
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  Data: <searchLink fieldCode="AU" term="%22Costa+Clemens+SA%22">Costa Clemens SA</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Institute of Global Health, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Weckx+L%22">Weckx L</searchLink>; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Clemens+R%22">Clemens R</searchLink>; International Vaccine Institute, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Almeida+Mendes+AV%22">Almeida Mendes AV</searchLink>; Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22Ramos+Souza+A%22">Ramos Souza A</searchLink>; Universidade Federal de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silveira+MBV%22">Silveira MBV</searchLink>; Universidade Federal de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Guarda+SNF%22">da Guarda SNF</searchLink>; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil; Department of Pediatrics, Universidade Federal da Bahia, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Nobrega+MM%22">de Nobrega MM</searchLink>; Universidade Federal de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Moraes+Pinto+MI%22">de Moraes Pinto MI</searchLink>; Universidade Federal de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonzalez+IGS%22">Gonzalez IGS</searchLink>; Universidade Federal de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Salvador+N%22">Salvador N</searchLink>; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22Franco+MM%22">Franco MM</searchLink>; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Avila+Mendonça+RN%22">de Avila Mendonça RN</searchLink>; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22Queiroz+Oliveira+IS%22">Queiroz Oliveira IS</searchLink>; General Medicine, Hospital São Rafael, Salvador, Brazil; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Freitas+Souza+BS%22">de Freitas Souza BS</searchLink>; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil; Gonçalo Moniz Institute, Fiocruz, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22Fraga+M%22">Fraga M</searchLink>; Instituto D'Or de Pesquisa e Ensino, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22Aley+P%22">Aley P</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bibi+S%22">Bibi S</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cantrell+L%22">Cantrell L</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dejnirattisai+W%22">Dejnirattisai W</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mongkolsapaya+J%22">Mongkolsapaya J</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Supasa+P%22">Supasa P</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Screaton+GR%22">Screaton GR</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Voysey+M%22">Voysey M</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+AJ%22">Pollard AJ</searchLink>; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: andrew.pollard@paediatrics.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2022 Feb 05; Vol. 399 (10324), pp. 521-529. <i>Date of Electronic Publication: </i>2022 Jan 21.
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  Data: Clinical Trial, Phase IV; Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial
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