Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS.
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| Title: | Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. |
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| Authors: | Hop PJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Hannon E; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Shireby GL; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Nabais MF; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK.; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia., Walker EM; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Dekker AM; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Westeneng HJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Tazelaar GHP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., van Eijk KR; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Moisse M; KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven 3000, Belgium.; VIB, Center for Brain and Disease Research, Leuven 3000, Belgium.; University Hospitals Leuven, Department of Neurology, Leuven 3000, Belgium., Baird D; Translational Biology, Biogen, Boston, MA 02142, USA.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol BS8 2BN, UK., Al Khleifat A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK., Iacoangeli A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.; National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London SE5 8AZ, UK., Ticozzi N; Department of Neurology-Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan 20149, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan 20122, Italy., Ratti A; Department of Neurology-Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan 20149, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano 20145, Italy., Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK., Morrison KE; School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7BL, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK., Basak AN; Koc University, School of Medicine, Translational Medicine Research Center, NDAL, Istanbul, 34450, Turkey., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin 10126, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin 10126, Italy., Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin 10126, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin 10126, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin 10126, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin 10126, Italy., Canosa A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin 10126, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin 10126, Italy., Brunetti M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin 10126, Italy., Grassano M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin 10126, Italy., Gotkine M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91904, Israel.; Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Medical Center, Jerusalem 91120, Israel., Lerner Y; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91904, Israel.; Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Medical Center, Jerusalem 91120, Israel., Zabari M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91904, Israel.; Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Medical Center, Jerusalem 91120, Israel., Vourc'h P; Service de Biochimie et Biologie moléculaire, CHU de Tours, Tours 37044, France.; UMR 1253, Université de Tours, Inserm, Tours 37044, France., Corcia P; UMR 1253, Université de Tours, Inserm, Tours 37044, France.; Centre de référence sur la SLA, CHU de Tours, Tours 37044, France., Couratier P; Centre de référence sur la SLA, CHRU de Limoges, Limoges 87042, France.; UMR 1094, Université de Limoges, Inserm, Limoges 87025, France., Mora Pardina JS; ALS Unit, Hospital San Rafael, Madrid, Spain., Salas T; Department of Neurology, Hospital La Paz-Carlos III, Madrid 28046, Spain., Dion P; Montréal Neurological Institute and Hospital, McGill University, Montréal, QC H3A 2B4, Canada., Ross JP; Montréal Neurological Institute and Hospital, McGill University, Montréal, QC H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada., Henderson RD; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, VIC 3195, Australia., McCombe PA; Centre for Clinical Research, University of Queensland, Brisbane, QLD 4019, Australia., Needham M; Fiona Stanley Hospital, Perth, WA 6150, Australia.; Notre Dame University, Fremantle, WA 6160, Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA 6150, Australia., Nicholson G; ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, NSW 2139, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Macquarie University, NSW 2109, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW 2031, Australia.; Neuroscience Research Australia Institute, Randwick, NSW 2031, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW 2031, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, UNSW, Randwick, NSW 2031, Australia., Furlong S; Centre for Motor Neuron Disease Research, Macquarie University, NSW 2109, Australia., Garton FC; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia., Henders AK; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia., Lin T; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia., Ngo ST; Centre for Clinical Research, University of Queensland, Brisbane, QLD 4019, Australia.; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4072, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia., Steyn FJ; Centre for Clinical Research, University of Queensland, Brisbane, QLD 4019, Australia.; School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia., Wallace L; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia., Williams KL; Centre for Motor Neuron Disease Research, Macquarie University, NSW 2109, Australia., Neto MM; Universidade de São Paulo, São Paulo 05508-070, Brazil., Cauchi RJ; Center for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, 2023 Msida, Malta., Blair IP; Centre for Motor Neuron Disease Research, Macquarie University, NSW 2109, Australia., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, NSW, 2050, Australia.; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia., Drory V; Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv 64239, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel., Povedano M; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona 08907, Spain., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon 1649-028, Portugal., Pinto S; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon 1649-028, Portugal., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland., Rouleau GA; Montréal Neurological Institute and Hospital, McGill University, Montréal, QC H3A 2B4, Canada., Silani V; Department of Neurology-Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan 20149, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan 20122, Italy., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA., Shaw CE; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK., Andersen PM; Department of Clinical Science, Umeå University, Umeå SE-901 85, Sweden., McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia., van Es MA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, 3584 CX, Netherlands., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD4072, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia., McLaughlin RL; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin D02 PN40, Ireland., Kenna KP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, 3584 CX, Netherlands., Tsai E; Translational Biology, Biogen, Boston, MA 02142, USA., Runz H; Translational Biology, Biogen, Boston, MA 02142, USA., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.; King's College Hospital, Denmark Hill, London SE5 9RS, UK., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands., Van Damme P; KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven 3000, Belgium.; VIB, Center for Brain and Disease Research, Leuven 3000, Belgium.; University Hospitals Leuven, Department of Neurology, Leuven 3000, Belgium., Mill J; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands. |
| Corporate Authors: | BIOS Consortium, Brain MEND Consortium |
| Source: | Science translational medicine [Sci Transl Med] 2022 Feb 23; Vol. 14 (633), pp. eabj0264. Date of Electronic Publication: 2022 Feb 23. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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