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Treatment of severe Kaposiform lymphangiomatosis positive for NRAS mutation by MEK inhibition.

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Title: Treatment of severe Kaposiform lymphangiomatosis positive for NRAS mutation by MEK inhibition.
Authors: Chowers G; Pediatrics B, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Abebe-Campino G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Hematology Oncology division, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Golan H; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Hematology Oncology division, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Vivante A; Pediatrics B, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Greenberger S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Dermatology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Soudack M; Pediatric Imaging Unit, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Barkai G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Infectious Diseases Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel., Fox-Fisher I; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel., Li D; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., March M; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Battig MR; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Divisions of Human Genetics and Pulmonary Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Adams D; Comprehensive Vascular Anomalies Program, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Dori Y; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Jill and Mark Fishman Center for Lymphatic Disorders, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dagan A; Pediatrics B, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel. daganay@gmail.com.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. daganay@gmail.com.; Pediatric Pulmonary Unit and the National Center for Cystic Fibrosis, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel. daganay@gmail.com.
Source: Pediatric research [Pediatr Res] 2023 Dec; Vol. 94 (6), pp. 1911-1915. Date of Electronic Publication: 2022 Mar 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
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  Data: Treatment of severe Kaposiform lymphangiomatosis positive for NRAS mutation by MEK inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Chowers+G%22">Chowers G</searchLink>; Pediatrics B, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Abebe-Campino+G%22">Abebe-Campino G</searchLink>; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Hematology Oncology division, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Golan+H%22">Golan H</searchLink>; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Hematology Oncology division, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Vivante+A%22">Vivante A</searchLink>; Pediatrics B, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Greenberger+S%22">Greenberger S</searchLink>; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Dermatology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Soudack+M%22">Soudack M</searchLink>; Pediatric Imaging Unit, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Barkai+G%22">Barkai G</searchLink>; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Infectious Diseases Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Fox-Fisher+I%22">Fox-Fisher I</searchLink>; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22March+M%22">March M</searchLink>; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Battig+MR%22">Battig MR</searchLink>; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hakonarson+H%22">Hakonarson H</searchLink>; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Divisions of Human Genetics and Pulmonary Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Adams+D%22">Adams D</searchLink>; Comprehensive Vascular Anomalies Program, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dori+Y%22">Dori Y</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Jill and Mark Fishman Center for Lymphatic Disorders, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dagan+A%22">Dagan A</searchLink>; Pediatrics B, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel. daganay@gmail.com.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. daganay@gmail.com.; Pediatric Pulmonary Unit and the National Center for Cystic Fibrosis, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel. daganay@gmail.com.
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        Value: 10.1038/s41390-022-01986-0
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