A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.

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Title:	A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.
Authors:	Yang E; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA., Metzloff M; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA., Langmüller AM; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Institut für Populationsgenetik, Vetmeduni Vienna, 1210 Wien, Austria.; Vienna Graduate School of Population Genetics, 1210 Wien, Austria., Xu X; Center for Bioinformatics, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., Clark AG; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA., Messer PW; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA., Champer J; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.; Center for Bioinformatics, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Source:	G3 (Bethesda, Md.) [G3 (Bethesda)] 2022 May 30; Vol. 12 (6).
Publication Type:	Journal Article; Research Support, N.I.H., Extramural
Journal Info:	Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE
Database:	MEDLINE Ultimate

FullText	Links: – Type: pdflink Text: Availability: 0
Header	DbId: mdl DbLabel: MEDLINE Ultimate An: 35394026 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0
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Items	– Name: Title Label: Title Group: Ti Data: A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yang+E%22">Yang E</searchLink>; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.<br /><searchLink fieldCode="AU" term="%22Metzloff+M%22">Metzloff M</searchLink>; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.<br /><searchLink fieldCode="AU" term="%22Langmüller+AM%22">Langmüller AM</searchLink>; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Institut für Populationsgenetik, Vetmeduni Vienna, 1210 Wien, Austria.; Vienna Graduate School of Population Genetics, 1210 Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Center for Bioinformatics, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Clark+AG%22">Clark AG</searchLink>; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.<br /><searchLink fieldCode="AU" term="%22Messer+PW%22">Messer PW</searchLink>; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.<br /><searchLink fieldCode="AU" term="%22Champer+J%22">Champer J</searchLink>; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.; Center for Bioinformatics, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101566598%22">G3 (Bethesda, Md.)</searchLink> [G3 (Bethesda)] 2022 May 30; Vol. 12 (6). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101566598 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2160-1836 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221601836%22">21601836 </searchLink><i>NLM ISO Abbreviation: </i>G3 (Bethesda) <i>Subsets: </i>MEDLINE
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RecordInfo	BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/g3journal/jkac081 Languages: – Code: eng Text: English Titles: – TitleFull: A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yang E – PersonEntity: Name: NameFull: Metzloff M – PersonEntity: Name: NameFull: Langmüller AM – PersonEntity: Name: NameFull: Xu X – PersonEntity: Name: NameFull: Clark AG – PersonEntity: Name: NameFull: Messer PW – PersonEntity: Name: NameFull: Champer J IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 05 Text: 2022 May 30 Type: published Y: 2022 Identifiers: – Type: issn-electronic Value: 2160-1836 Numbering: – Type: volume Value: 12 – Type: issue Value: 6 Titles: – TitleFull: G3 (Bethesda, Md.) Type: main
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