A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.
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| Title: | A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles. |
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| Authors: | Yang E; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA., Metzloff M; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA., Langmüller AM; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Institut für Populationsgenetik, Vetmeduni Vienna, 1210 Wien, Austria.; Vienna Graduate School of Population Genetics, 1210 Wien, Austria., Xu X; Center for Bioinformatics, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., Clark AG; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA., Messer PW; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA., Champer J; Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.; Center for Bioinformatics, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. |
| Source: | G3 (Bethesda, Md.) [G3 (Bethesda)] 2022 May 30; Vol. 12 (6). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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