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Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells.

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Title: Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells.
Authors: Khilji MS; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.; Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan., Faridi P; Department of Medicine, School of Clinical Sciences, Monash Univesity, Clayton, VIC 3168, Australia., Pinheiro-Machado E; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Hoefner C; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Dahlby T; Laboratory of Translational Nutrition Biology, Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zürich, 8603 Zürich, Switzerland., Aranha R; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia., Buus S; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark., Nielsen M; Department of Health Technology, Section for Bioinformatics, Technical University of Denmark, 2800 Lyngby, Denmark.; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín CP1650, Argentina., Klusek J; Laboratory of Medical Genetics, Department of Surgical Medicine, Collegium Medicum, Jan Kochanowski University, 25-369 Kielce, Poland., Mandrup-Poulsen T; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Pandey K; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia., Purcell AW; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia., Marzec MT; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Institute of Health Sciences, Collegium Medicum, Jan Kochanowski University, 25-002 Kielce, Poland.
Source: Biomedicines [Biomedicines] 2022 Mar 30; Vol. 10 (4). Date of Electronic Publication: 2022 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells.
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  Data: <searchLink fieldCode="AU" term="%22Khilji+MS%22">Khilji MS</searchLink>; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.; Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.<br /><searchLink fieldCode="AU" term="%22Faridi+P%22">Faridi P</searchLink>; Department of Medicine, School of Clinical Sciences, Monash Univesity, Clayton, VIC 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Pinheiro-Machado+E%22">Pinheiro-Machado E</searchLink>; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoefner+C%22">Hoefner C</searchLink>; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dahlby+T%22">Dahlby T</searchLink>; Laboratory of Translational Nutrition Biology, Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zürich, 8603 Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aranha+R%22">Aranha R</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Buus+S%22">Buus S</searchLink>; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+M%22">Nielsen M</searchLink>; Department of Health Technology, Section for Bioinformatics, Technical University of Denmark, 2800 Lyngby, Denmark.; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín CP1650, Argentina.<br /><searchLink fieldCode="AU" term="%22Klusek+J%22">Klusek J</searchLink>; Laboratory of Medical Genetics, Department of Surgical Medicine, Collegium Medicum, Jan Kochanowski University, 25-369 Kielce, Poland.<br /><searchLink fieldCode="AU" term="%22Mandrup-Poulsen+T%22">Mandrup-Poulsen T</searchLink>; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pandey+K%22">Pandey K</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Purcell+AW%22">Purcell AW</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Marzec+MT%22">Marzec MT</searchLink>; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Institute of Health Sciences, Collegium Medicum, Jan Kochanowski University, 25-002 Kielce, Poland.
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