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Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.

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Title: Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.
Authors: Howe LJ; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. laurence.howe@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. laurence.howe@bristol.ac.uk., Nivard MG; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands., Morris TT; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hansen AF; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Rasheed H; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Cho Y; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Chittoor G; Department of Population Health Sciences, Geisinger Health, Danville, PA, USA., Ahlskog R; Department of Government, Uppsala University, Uppsala, Sweden., Lind PA; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia., Palviainen T; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., van der Zee MD; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands., Cheesman R; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Wang Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Li S; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Klaric L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Ratliff SM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Nygaard M; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Giannelis A; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Willoughby EA; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Reynolds CA; Department of Psychology, University of California, Riverside, Riverside, CA, USA., Balbona JV; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Ask H; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway., Baras A; Regeneron Genetics Center, Tarrytown, NY, USA., Bauer CR; BioMarin Pharmaceutical Inc., Novato, CA, USA.; Biomedical and Translational Informatics, Geisinger Health, Danville, PA, USA., Boomsma DI; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health (APH) and Amsterdam Reproduction and Development (AR&D), Amsterdam, the Netherlands., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Campbell H; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Corfield E; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Dahm CC; Department of Public Health, Aarhus University, Aarhus, Denmark., Dokuru DR; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Evans LM; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado at Boulder, Boulder, CO, USA., de Geus EJC; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands., Giddaluru S; Institute of Health and Society, University of Oslo, Oslo, Norway.; Norwegian Institute of Public Health, Oslo, Norway., Gordon SD; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Harden KP; Department of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA., Hill WD; Lothian Birth Cohorts Group, Department of Psychology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Hughes A; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kerr SM; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kim Y; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Kweon H; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Latvala A; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.; Institute of Criminology and Legal Policy, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland., Lawlor DA; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol NIHR Biomedical Research Centre, Bristol, UK., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Magnus P; Centre for Fertility and Health, Norwegian Institute of Public Health, Skøyen, Oslo, Norway., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mallard TT; Department of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA., Martikainen P; Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.; The Max Planck Institute for Demographic Research, Rostock, Germany.; Department of Public Health Sciences, Stockholm University, Stockholm, Sweden., Mills MC; Leverhulme Centre for Demographic Science, University of Oxford, Oxford, UK., Njølstad PR; Department of Clinical Science, University of Bergen, Bergen, Norway.; Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway., Overton JD; Regeneron Genetics Center, Tarrytown, NY, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Reid J; Regeneron Genetics Center, Tarrytown, NY, USA., Silventoinen K; Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland., Southey MC; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia., Stoltenberg C; Norwegian Institute of Public Health, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Tucker-Drob EM; Department of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA., Wright MJ; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia., Hewitt JK; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Keller MC; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Stallings MC; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Lee JJ; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Christensen K; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia., Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Pingault JB; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Department of Clinical, Educational and Health Psychology, University College London, London, UK., Plomin R; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Havdahl A; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Bartels M; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands., Martin NG; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Oskarsson S; Department of Government, Uppsala University, Uppsala, Sweden., Justice AE; Department of Population Health Sciences, Geisinger Health, Danville, PA, USA., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Naess Ø; Institute of Health and Society, University of Oslo, Oslo, Norway.; Norwegian Institute of Public Health, Oslo, Norway., Willer CJ; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Koellinger PD; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA., Kaprio J; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; School of Psychology, University of Queensland, Brisbane, Queensland, Australia., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Benjamin DJ; UCLA Anderson School of Management, Los Angeles, CA, USA.; Human Genetics Department, UCLA David Geffen School of Medicine, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, CA, USA.; National Bureau of Economic Research, Cambridge, MA, USA., Turley P; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.; Department of Economics, University of Southern California, Los Angeles, CA, USA., Evans DM; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Davey Smith G; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Brumpton B; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. ben.brumpton@ntnu.no.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. ben.brumpton@ntnu.no.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway. ben.brumpton@ntnu.no., Hemani G; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk., Davies NM; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. neil.davies@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. neil.davies@bristol.ac.uk.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. neil.davies@bristol.ac.uk.
Corporate Authors: Social Science Genetic Association Consortium, Within Family Consortium
Source: Nature genetics [Nat Genet] 2022 May; Vol. 54 (5), pp. 581-592. Date of Electronic Publication: 2022 May 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.
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  Data: <searchLink fieldCode="AU" term="%22Howe+LJ%22">Howe LJ</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. laurence.howe@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. laurence.howe@bristol.ac.uk.<br /><searchLink fieldCode="AU" term="%22Nivard+MG%22">Nivard MG</searchLink>; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Morris+TT%22">Morris TT</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hansen+AF%22">Hansen AF</searchLink>; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Rasheed+H%22">Rasheed H</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Cho+Y%22">Cho Y</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Chittoor+G%22">Chittoor G</searchLink>; Department of Population Health Sciences, Geisinger Health, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ahlskog+R%22">Ahlskog R</searchLink>; Department of Government, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lind+PA%22">Lind PA</searchLink>; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Palviainen+T%22">Palviainen T</searchLink>; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22van+der+Zee+MD%22">van der Zee MD</searchLink>; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cheesman+R%22">Cheesman R</searchLink>; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mangino+M%22">Mangino M</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Klaric+L%22">Klaric L</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Ratliff+SM%22">Ratliff SM</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bielak+LF%22">Bielak LF</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Nygaard+M%22">Nygaard M</searchLink>; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Giannelis+A%22">Giannelis A</searchLink>; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Willoughby+EA%22">Willoughby EA</searchLink>; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Reynolds+CA%22">Reynolds CA</searchLink>; Department of Psychology, University of California, Riverside, Riverside, CA, USA.<br /><searchLink fieldCode="AU" term="%22Balbona+JV%22">Balbona JV</searchLink>; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; NORMENT Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Ask+H%22">Ask H</searchLink>; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Baras+A%22">Baras A</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bauer+CR%22">Bauer CR</searchLink>; BioMarin Pharmaceutical Inc., Novato, CA, USA.; Biomedical and Translational Informatics, Geisinger Health, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Boomsma+DI%22">Boomsma DI</searchLink>; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health (APH) and Amsterdam Reproduction and Development (AR&D), Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Campbell+A%22">Campbell A</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+H%22">Campbell H</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Christofidou+P%22">Christofidou P</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Corfield+E%22">Corfield E</searchLink>; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Dahm+CC%22">Dahm CC</searchLink>; Department of Public Health, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Dokuru+DR%22">Dokuru DR</searchLink>; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Evans+LM%22">Evans LM</searchLink>; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.; Department of Ecology & Evolutionary Biology, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22de+Geus+EJC%22">de Geus EJC</searchLink>; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Giddaluru+S%22">Giddaluru S</searchLink>; Institute of Health and Society, University of Oslo, Oslo, Norway.; Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Gordon+SD%22">Gordon SD</searchLink>; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Harden+KP%22">Harden KP</searchLink>; Department of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hill+WD%22">Hill WD</searchLink>; Lothian Birth Cohorts Group, Department of Psychology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hughes+A%22">Hughes A</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Kerr+SM%22">Kerr SM</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Kweon+H%22">Kweon H</searchLink>; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Latvala+A%22">Latvala A</searchLink>; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.; Institute of Criminology and Legal Policy, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lawlor+DA%22">Lawlor DA</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol NIHR Biomedical Research Centre, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Magnus+P%22">Magnus P</searchLink>; Centre for Fertility and Health, Norwegian Institute of Public Health, Skøyen, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Magnusson+PKE%22">Magnusson PKE</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Mallard+TT%22">Mallard TT</searchLink>; Department of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Martikainen+P%22">Martikainen P</searchLink>; Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.; The Max Planck Institute for Demographic Research, Rostock, Germany.; Department of Public Health Sciences, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Mills+MC%22">Mills MC</searchLink>; Leverhulme Centre for Demographic Science, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Njølstad+PR%22">Njølstad PR</searchLink>; Department of Clinical Science, University of Bergen, Bergen, Norway.; Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Overton+JD%22">Overton JD</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pedersen+NL%22">Pedersen NL</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Porteous+DJ%22">Porteous DJ</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Reid+J%22">Reid J</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Silventoinen+K%22">Silventoinen K</searchLink>; Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Southey+MC%22">Southey MC</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Stoltenberg+C%22">Stoltenberg C</searchLink>; Norwegian Institute of Public Health, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Tucker-Drob+EM%22">Tucker-Drob EM</searchLink>; Department of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wright+MJ%22">Wright MJ</searchLink>; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Hewitt+JK%22">Hewitt JK</searchLink>; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Keller+MC%22">Keller MC</searchLink>; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Stallings+MC%22">Stallings MC</searchLink>; Department of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Christensen+K%22">Christensen K</searchLink>; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Kardia+SLR%22">Kardia SLR</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Peyser+PA%22">Peyser PA</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+JF%22">Wilson JF</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hopper+JL%22">Hopper JL</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hägg+S%22">Hägg S</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Spector+TD%22">Spector TD</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pingault+JB%22">Pingault JB</searchLink>; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Department of Clinical, Educational and Health Psychology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Plomin+R%22">Plomin R</searchLink>; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Havdahl+A%22">Havdahl A</searchLink>; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bartels+M%22">Bartels M</searchLink>; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Martin+NG%22">Martin NG</searchLink>; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Oskarsson+S%22">Oskarsson S</searchLink>; Department of Government, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Justice+AE%22">Justice AE</searchLink>; Department of Population Health Sciences, Geisinger Health, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Millwood+IY%22">Millwood IY</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Naess+Ø%22">Naess Ø</searchLink>; Institute of Health and Society, University of Oslo, Oslo, Norway.; Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Willer+CJ%22">Willer CJ</searchLink>; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Åsvold+BO%22">Åsvold BO</searchLink>; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Koellinger+PD%22">Koellinger PD</searchLink>; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Kaprio+J%22">Kaprio J</searchLink>; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Medland+SE%22">Medland SE</searchLink>; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; School of Psychology, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Walters+RG%22">Walters RG</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Benjamin+DJ%22">Benjamin DJ</searchLink>; UCLA Anderson School of Management, Los Angeles, CA, USA.; Human Genetics Department, UCLA David Geffen School of Medicine, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, CA, USA.; National Bureau of Economic Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Turley+P%22">Turley P</searchLink>; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.; Department of Economics, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Evans+DM%22">Evans DM</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Davey+Smith+G%22">Davey Smith G</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Brumpton+B%22">Brumpton B</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. ben.brumpton@ntnu.no.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. ben.brumpton@ntnu.no.; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway. ben.brumpton@ntnu.no.<br /><searchLink fieldCode="AU" term="%22Hemani+G%22">Hemani G</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk.<br /><searchLink fieldCode="AU" term="%22Davies+NM%22">Davies NM</searchLink>; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. neil.davies@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. neil.davies@bristol.ac.uk.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. neil.davies@bristol.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2022 May; Vol. 54 (5), pp. 581-592. <i>Date of Electronic Publication: </i>2022 May 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
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      – TitleFull: Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.
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      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2022 May
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1