GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.

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Title: GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Authors: Nuermberger EL; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Martínez-Martínez MS; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Sanz O; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Urones B; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Esquivias J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Soni H; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Tasneen R; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Tyagi S; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Li SY; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Converse PJ; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Robertson GT; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., Besra GS; Institute of Microbiology and Infection, School of Biosciences, University of Birminghamgrid.6572.6, Birmingham, United Kingdom., Abrahams KA; Institute of Microbiology and Infection, School of Biosciences, University of Birminghamgrid.6572.6, Birmingham, United Kingdom., Upton AM; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Mdluli K; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Boyle GW; GSK: Research, GlaxoSmithKline R&D, Ware, United Kingdom., Turner S; GSK: Research, GlaxoSmithKline R&D, Ware, United Kingdom., Fotouhi N; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Cammack NC; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Siles JM; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Alonso M; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Escribano J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Lelievre J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Rullas-Trincado J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Pérez-Herrán E; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Bates RH; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Maher-Edwards G; GSK, Brentford, Middlesex, United Kingdom., Barros D; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Ballell L; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Jiménez E; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Jun 21; Vol. 66 (6), pp. e0013222. Date of Electronic Publication: 2022 May 24.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
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  Data: <searchLink fieldCode="AU" term="%22Nuermberger+EL%22">Nuermberger EL</searchLink>; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Martínez-Martínez+MS%22">Martínez-Martínez MS</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+O%22">Sanz O</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Urones+B%22">Urones B</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Esquivias+J%22">Esquivias J</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Soni+H%22">Soni H</searchLink>; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Tasneen+R%22">Tasneen R</searchLink>; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Tyagi+S%22">Tyagi S</searchLink>; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Li+SY%22">Li SY</searchLink>; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Converse+PJ%22">Converse PJ</searchLink>; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Boshoff+HI%22">Boshoff HI</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Robertson+GT%22">Robertson GT</searchLink>; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Besra+GS%22">Besra GS</searchLink>; Institute of Microbiology and Infection, School of Biosciences, University of Birminghamgrid.6572.6, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Abrahams+KA%22">Abrahams KA</searchLink>; Institute of Microbiology and Infection, School of Biosciences, University of Birminghamgrid.6572.6, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Upton+AM%22">Upton AM</searchLink>; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Mdluli+K%22">Mdluli K</searchLink>; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Boyle+GW%22">Boyle GW</searchLink>; GSK: Research, GlaxoSmithKline R&D, Ware, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Turner+S%22">Turner S</searchLink>; GSK: Research, GlaxoSmithKline R&D, Ware, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fotouhi+N%22">Fotouhi N</searchLink>; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Cammack+NC%22">Cammack NC</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Siles+JM%22">Siles JM</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso+M%22">Alonso M</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Escribano+J%22">Escribano J</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lelievre+J%22">Lelievre J</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rullas-Trincado+J%22">Rullas-Trincado J</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Herrán+E%22">Pérez-Herrán E</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bates+RH%22">Bates RH</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Maher-Edwards+G%22">Maher-Edwards G</searchLink>; GSK, Brentford, Middlesex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Barros+D%22">Barros D</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ballell+L%22">Ballell L</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2022 Jun 21; Vol. 66 (6), pp. e0013222. <i>Date of Electronic Publication: </i>2022 May 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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