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Granzyme K+ CD8 T cells form a core population in inflamed human tissue.

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Title: Granzyme K+ CD8 T cells form a core population in inflamed human tissue.
Authors: Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Zhang F; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology and Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO 80045, USA., Dunlap G; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Gomez-Rivas E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Faust HJ; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Rupani KV; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Mears JR; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Meednu N; Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA., Wang R; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Keras G; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Coblyn JS; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Massarotti EM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Todd DJ; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Anolik JH; Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA., McDavid A; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Rao DA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester M13 9PT, UK., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Corporate Authors: Accelerating Medicines Partnership RA/SLE Network
Source: Science translational medicine [Sci Transl Med] 2022 Jun 15; Vol. 14 (649), pp. eabo0686. Date of Electronic Publication: 2022 Jun 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Granzyme K<superscript>+</superscript> CD8 T cells form a core population in inflamed human tissue.
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