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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.

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Title: PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.
Authors: Patel AJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Warda S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Maag JLV; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Misra R; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York., Miranda-Román MA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York., Pachai MR; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Lee CJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Li D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Wang N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Bayshtok G; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Fishinevich E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Meng Y; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York., Wong EWP; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Yan J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Giff E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Pappalardi MB; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, Pennsylvania., McCabe MT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, Pennsylvania., Fletcher JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Rudin CM; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Chandarlapaty S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York., Scandura JM; Laboratory of Molecular Hematopoiesis, Hematology and Oncology, Weill Cornell Medicine, New York, New York.; Richard T. Silver MD Myeloproliferative Neoplasm Center, Weill Cornell Medicine, New York, New York.; Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York., Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Glass JL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York., Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Zheng D; The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York., Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York., Chi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York.
Source: Cancer discovery [Cancer Discov] 2022 Sep 02; Vol. 12 (9), pp. 2120-2139.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.
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Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Pachai+MR%22">Pachai MR</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Lee+CJ%22">Lee CJ</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Bayshtok+G%22">Bayshtok G</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Fishinevich+E%22">Fishinevich E</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Meng+Y%22">Meng Y</searchLink>; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wong+EWP%22">Wong EWP</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Yan+J%22">Yan J</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Giff+E%22">Giff E</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Pappalardi+MB%22">Pappalardi MB</searchLink>; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22McCabe+MT%22">McCabe MT</searchLink>; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Fletcher+JA%22">Fletcher JA</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rudin+CM%22">Rudin CM</searchLink>; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chandarlapaty+S%22">Chandarlapaty S</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Scandura+JM%22">Scandura JM</searchLink>; Laboratory of Molecular Hematopoiesis, Hematology and Oncology, Weill Cornell Medicine, New York, New York.; Richard T. Silver MD Myeloproliferative Neoplasm Center, Weill Cornell Medicine, New York, New York.; Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Koche+RP%22">Koche RP</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Glass+JL%22">Glass JL</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Antonescu+CR%22">Antonescu CR</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Zheng+D%22">Zheng D</searchLink>; The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chi+P%22">Chi P</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York.
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