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Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection.

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Title: Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection.
Authors: Bender Ignacio RA; Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Wohl DA; Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Arends R; Clinical Pharmacology and Quantitative Pharmacology, Vaccines & Immunotherapies, Neuroscience and Clinical Immunogenicity, AstraZeneca, Cambridge, UK., Pilla Reddy V; Clinical Pharmacology and Quantitative Pharmacology, Vaccines & Immunotherapies, Neuroscience and Clinical Immunogenicity, AstraZeneca, Cambridge, UK., Mu Y; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska, USA., Javan AC; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Hughes MD; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Eron JJ; Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Currier JS; Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA., Smith D; Division of Infectious Diseases and Global Public Health, University of California - San Diego, San Diego, California, USA., Chew KW; Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA., Gibbs M; Clinical Pharmacology and Quantitative Pharmacology, Vaccines & Immunotherapies, Neuroscience and Clinical Immunogenicity, AstraZeneca, Cambridge, UK., Fletcher CV; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Dec; Vol. 112 (6), pp. 1207-1213. Date of Electronic Publication: 2022 Jul 26.
Publication Type: Randomized Controlled Trial; Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection.
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  Data: <searchLink fieldCode="AU" term="%22Bender+Ignacio+RA%22">Bender Ignacio RA</searchLink>; Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wohl+DA%22">Wohl DA</searchLink>; Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Arends+R%22">Arends R</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Vaccines & Immunotherapies, Neuroscience and Clinical Immunogenicity, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pilla+Reddy+V%22">Pilla Reddy V</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Vaccines & Immunotherapies, Neuroscience and Clinical Immunogenicity, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mu+Y%22">Mu Y</searchLink>; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska, USA.<br /><searchLink fieldCode="AU" term="%22Javan+AC%22">Javan AC</searchLink>; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+MD%22">Hughes MD</searchLink>; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Eron+JJ%22">Eron JJ</searchLink>; Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Currier+JS%22">Currier JS</searchLink>; Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Smith+D%22">Smith D</searchLink>; Division of Infectious Diseases and Global Public Health, University of California - San Diego, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Chew+KW%22">Chew KW</searchLink>; Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Gibbs+M%22">Gibbs M</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Vaccines & Immunotherapies, Neuroscience and Clinical Immunogenicity, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fletcher+CV%22">Fletcher CV</searchLink>; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
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