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Depatuxizumab mafodotin in EGFR-amplified newly diagnosed glioblastoma: A phase III randomized clinical trial.

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Title: Depatuxizumab mafodotin in EGFR-amplified newly diagnosed glioblastoma: A phase III randomized clinical trial.
Authors: Lassman AB; Division of Neuro-Oncology, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Pugh SL; RTOG Foundation Statistics and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania., Wang TJC; Department of Radiation Oncology (in Neurological Surgery), Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Aldape K; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., Gan HK; Cancer Therapies and Biology Group, Centre of Research Excellence in Brain Tumours, Olivia Newton-John Cancer Wellness and Research Centre, Austin Hospital, Heidelberg, Melbourne, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia.; Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia., Preusser M; Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria., Vogelbaum MA; Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, Florida, USA., Sulman EP; Department of Radiation Oncology, New York University, Grossman School of Medicine, New York, New York, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA., Won M; RTOG Foundation Statistics and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania., Zhang P; RTOG Foundation Statistics and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania., Moazami G; Department of Ophthalmology, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, New York, USA., Macsai MS; NorthShore University HealthSystem, Department of Ophthalmology, University of Chicago Pritzker School of Medicine, Evanston, Illinois, USA., Gilbert MR; Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Bain EE; Abbvie, Inc., North Chicago, Illinois, USA., Blot V; Abbvie, Inc., North Chicago, Illinois, USA., Ansell PJ; Abbvie, Inc., North Chicago, Illinois, USA., Samanta S; Abbvie, Inc., North Chicago, Illinois, USA., Kundu MG; Abbvie, Inc., North Chicago, Illinois, USA., Armstrong TS; Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, USA., Wefel JS; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Seidel C; University Hospital Leipzig, Leipzig, Germany., de Vos FY; University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands., Hsu S; Department of Neurosurgery, University of Texas Health Sciences Center, McGovern School of Medicine, Houston, Texas, USA., Cardona AF; Foundation for Clinical and Applied Cancer Research-FICMAC/Clinical and Translational Oncology Group, Brain Tumor Section, Bogotá, Colombia., Lombardi G; Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy., Bentsion D; Sverdlovsk Regional Oncology Center, Ekaterinburg, Russia., Peterson RA; Metro Minnesota NCORP, Saint Paul, Minnesota, USA., Gedye C; Calvary Mater Newcastle, Waratah, New South Wales, Australia., Bourg V; Department of Neurology, Côte d'Azur University, Nice, France., Wick A; Heidelberg University Medical Center, Heidelberg, Germany., Curran WJ; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Mehta MP; Miami Cancer Institute, Baptist Hospital, Miami, Florida, USA.
Source: Neuro-oncology [Neuro Oncol] 2023 Feb 14; Vol. 25 (2), pp. 339-350.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase III; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
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  Data: Depatuxizumab mafodotin in EGFR-amplified newly diagnosed glioblastoma: A phase III randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Lassman+AB%22">Lassman AB</searchLink>; Division of Neuro-Oncology, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Pugh+SL%22">Pugh SL</searchLink>; RTOG Foundation Statistics and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wang+TJC%22">Wang TJC</searchLink>; Department of Radiation Oncology (in Neurological Surgery), Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Aldape+K%22">Aldape K</searchLink>; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gan+HK%22">Gan HK</searchLink>; Cancer Therapies and Biology Group, Centre of Research Excellence in Brain Tumours, Olivia Newton-John Cancer Wellness and Research Centre, Austin Hospital, Heidelberg, Melbourne, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia.; Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Preusser+M%22">Preusser M</searchLink>; Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Vogelbaum+MA%22">Vogelbaum MA</searchLink>; Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Sulman+EP%22">Sulman EP</searchLink>; Department of Radiation Oncology, New York University, Grossman School of Medicine, New York, New York, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Won+M%22">Won M</searchLink>; RTOG Foundation Statistics and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; RTOG Foundation Statistics and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Moazami+G%22">Moazami G</searchLink>; Department of Ophthalmology, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Macsai+MS%22">Macsai MS</searchLink>; NorthShore University HealthSystem, Department of Ophthalmology, University of Chicago Pritzker School of Medicine, Evanston, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+MR%22">Gilbert MR</searchLink>; Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bain+EE%22">Bain EE</searchLink>; Abbvie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Blot+V%22">Blot V</searchLink>; Abbvie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Ansell+PJ%22">Ansell PJ</searchLink>; Abbvie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Samanta+S%22">Samanta S</searchLink>; Abbvie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Kundu+MG%22">Kundu MG</searchLink>; Abbvie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Armstrong+TS%22">Armstrong TS</searchLink>; Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wefel+JS%22">Wefel JS</searchLink>; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Seidel+C%22">Seidel C</searchLink>; University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22de+Vos+FY%22">de Vos FY</searchLink>; University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hsu+S%22">Hsu S</searchLink>; Department of Neurosurgery, University of Texas Health Sciences Center, McGovern School of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Cardona+AF%22">Cardona AF</searchLink>; Foundation for Clinical and Applied Cancer Research-FICMAC/Clinical and Translational Oncology Group, Brain Tumor Section, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Lombardi+G%22">Lombardi G</searchLink>; Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Bentsion+D%22">Bentsion D</searchLink>; Sverdlovsk Regional Oncology Center, Ekaterinburg, Russia.<br /><searchLink fieldCode="AU" term="%22Peterson+RA%22">Peterson RA</searchLink>; Metro Minnesota NCORP, Saint Paul, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Gedye+C%22">Gedye C</searchLink>; Calvary Mater Newcastle, Waratah, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Bourg+V%22">Bourg V</searchLink>; Department of Neurology, Côte d'Azur University, Nice, France.<br /><searchLink fieldCode="AU" term="%22Wick+A%22">Wick A</searchLink>; Heidelberg University Medical Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Curran+WJ%22">Curran WJ</searchLink>; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+MP%22">Mehta MP</searchLink>; Miami Cancer Institute, Baptist Hospital, Miami, Florida, USA.
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  Data: Randomized Controlled Trial; Clinical Trial, Phase III; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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