Addition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome.

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Title: Addition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome.
Authors: Janssen JJWM; Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, loc. VUmc, Amsterdam, The Netherlands. j.janssen@amsterdamumc.nl., Löwenberg B; Department of Hematology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Manz M; USZ Zürich, Zürich, Switzerland.; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands., Biemond BJ; Department of Hematology, Amsterdam University Medical Centers, loc. AMC, Amsterdam, The Netherlands., Westerweel PE; Albert Schweitzer Hospital, Dordrecht, The Netherlands., Klein SK; Department of Hematology, University Medical Center, Groningen, The Netherlands., Fehr M; Kantonsspital St. Gallen, St. Gallen, Switzerland., Sinnige HAM; Jeroen Bosch Hospital, Den Bosch, The Netherlands., Efthymiou A; HFR, Fribourg, Switzerland., Legdeur MCJC; Medisch Spectrum Twente, Enschede, The Netherlands., Pabst T; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; Department of Medical Oncology, University Hospital Inselspital and University of Bern, Bern, Switzerland., Gregor M; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; KSL, Luzern, Switzerland., van der Poel MWM; Dept. of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands., Deeren D; AZ Delta, Roeselare, Belgium., Tick LW; Maxima Medical Center, Eindhoven, The Netherlands., Jongen-Lavrencic M; Department of Hematology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands., van Obbergh F; Hospital Saint Paul Jolimont, Haine, Belgium., Boersma RS; Amphia Hospital, Breda, The Netherlands., de Weerdt O; Antonius Hospital, Nieuwegein, The Netherlands., Chalandon Y; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; Division of Hematology, Department of Oncology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland., Heim D; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; University Hospital, Basel, Switzerland., Spertini O; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., van Sluis G; Isala Clinics, Zwolle, The Netherlands., Graux C; Mont Godinne, Yvoir, Belgium., Stüssi G; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; IOSI, Belinzona, Switzerland., van Norden Y; Hovon Data Center, Erasmus Medical Center, Rotterdam, The Netherlands., Ossenkoppele GJ; Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, loc. VUmc, Amsterdam, The Netherlands.
Source: Leukemia [Leukemia] 2022 Sep; Vol. 36 (9), pp. 2189-2195. Date of Electronic Publication: 2022 Jul 22.
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Addition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Janssen+JJWM%22">Janssen JJWM</searchLink>; Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, loc. VUmc, Amsterdam, The Netherlands. j.janssen@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Löwenberg+B%22">Löwenberg B</searchLink>; Department of Hematology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Manz+M%22">Manz M</searchLink>; USZ Zürich, Zürich, Switzerland.; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Biemond+BJ%22">Biemond BJ</searchLink>; Department of Hematology, Amsterdam University Medical Centers, loc. AMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Westerweel+PE%22">Westerweel PE</searchLink>; Albert Schweitzer Hospital, Dordrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Klein+SK%22">Klein SK</searchLink>; Department of Hematology, University Medical Center, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Fehr+M%22">Fehr M</searchLink>; Kantonsspital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sinnige+HAM%22">Sinnige HAM</searchLink>; Jeroen Bosch Hospital, Den Bosch, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Efthymiou+A%22">Efthymiou A</searchLink>; HFR, Fribourg, Switzerland.<br /><searchLink fieldCode="AU" term="%22Legdeur+MCJC%22">Legdeur MCJC</searchLink>; Medisch Spectrum Twente, Enschede, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pabst+T%22">Pabst T</searchLink>; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; Department of Medical Oncology, University Hospital Inselspital and University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gregor+M%22">Gregor M</searchLink>; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; KSL, Luzern, Switzerland.<br /><searchLink fieldCode="AU" term="%22van+der+Poel+MWM%22">van der Poel MWM</searchLink>; Dept. of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Deeren+D%22">Deeren D</searchLink>; AZ Delta, Roeselare, Belgium.<br /><searchLink fieldCode="AU" term="%22Tick+LW%22">Tick LW</searchLink>; Maxima Medical Center, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jongen-Lavrencic+M%22">Jongen-Lavrencic M</searchLink>; Department of Hematology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Obbergh+F%22">van Obbergh F</searchLink>; Hospital Saint Paul Jolimont, Haine, Belgium.<br /><searchLink fieldCode="AU" term="%22Boersma+RS%22">Boersma RS</searchLink>; Amphia Hospital, Breda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Weerdt+O%22">de Weerdt O</searchLink>; Antonius Hospital, Nieuwegein, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chalandon+Y%22">Chalandon Y</searchLink>; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; Division of Hematology, Department of Oncology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Heim+D%22">Heim D</searchLink>; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; University Hospital, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Spertini+O%22">Spertini O</searchLink>; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22van+Sluis+G%22">van Sluis G</searchLink>; Isala Clinics, Zwolle, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Graux+C%22">Graux C</searchLink>; Mont Godinne, Yvoir, Belgium.<br /><searchLink fieldCode="AU" term="%22Stüssi+G%22">Stüssi G</searchLink>; SAKK Swiss Clinical Cancer Research Group, Amsterdam, The Netherlands.; IOSI, Belinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22van+Norden+Y%22">van Norden Y</searchLink>; Hovon Data Center, Erasmus Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ossenkoppele+GJ%22">Ossenkoppele GJ</searchLink>; Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, loc. VUmc, Amsterdam, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2022 Sep; Vol. 36 (9), pp. 2189-2195. <i>Date of Electronic Publication: </i>2022 Jul 22.
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