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Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

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Title: Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Authors: Reichart D; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine I, University Hospital, LMU Munich, 80336 Munich, Germany., Lindberg EL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Maatz H; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany., Miranda AMA; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; British Heart Foundation Centre for Research Excellence and Centre for Regenerative Medicine, Imperial College London, London WC2R 2LS, UK., Viveiros A; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Shvetsov N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Gärtner A; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany., Nadelmann ER; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Lee M; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Kanemaru K; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Ruiz-Orera J; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Strohmenger V; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilian University of Munich, 81377 Munich, Germany., DeLaughter DM; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Bethesda, MD 20815, USA., Patone G; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Zhang H; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Woehler A; Systems Biology Imaging Platform, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany., Lippert C; Digital Health-Machine Learning group, Hasso Plattner Institute for Digital Engineering, University of Potsdam, 14482 Potsdam, Germany.; Hasso Plattner Institute for Digital Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Kim Y; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA., Adami E; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Gorham JM; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Barnett SN; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Brown K; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Buchan RJ; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK., Chowdhury RA; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Constantinou C; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Cranley J; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Felkin LE; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK., Fox H; Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany., Ghauri A; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Gummert J; Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany., Kanda M; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; Department of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan., Li R; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Mach L; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK., McDonough B; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Bethesda, MD 20815, USA., Samari S; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Shahriaran F; Computational Health Center, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany., Yapp C; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Stanasiuk C; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany., Theotokis PI; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Theis FJ; Computational Health Center, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany., van den Bogaerdt A; ETB-Bislife Foundation, 2300 AH Leiden, Netherlands., Wakimoto H; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Ware JS; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Worth CL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Barton PJR; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Lee YA; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany., Teichmann SA; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK., Milting H; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany., Noseda M; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; British Heart Foundation Centre for Research Excellence and Centre for Regenerative Medicine, Imperial College London, London WC2R 2LS, UK., Oudit GY; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Heinig M; Computational Health Center, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany.; Department of Informatics, Technische Universitaet Muenchen (TUM), 85748 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Munich Heart Association, Partner Site Munich, 10785 Berlin, Germany., Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Hubner N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Bethesda, MD 20815, USA.
Source: Science (New York, N.Y.) [Science] 2022 Aug 05; Vol. 377 (6606), pp. eabo1984. Date of Electronic Publication: 2022 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
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            NameFull: Constantinou C
      – PersonEntity:
          Name:
            NameFull: Cranley J
      – PersonEntity:
          Name:
            NameFull: Felkin LE
      – PersonEntity:
          Name:
            NameFull: Fox H
      – PersonEntity:
          Name:
            NameFull: Ghauri A
      – PersonEntity:
          Name:
            NameFull: Gummert J
      – PersonEntity:
          Name:
            NameFull: Kanda M
      – PersonEntity:
          Name:
            NameFull: Li R
      – PersonEntity:
          Name:
            NameFull: Mach L
      – PersonEntity:
          Name:
            NameFull: McDonough B
      – PersonEntity:
          Name:
            NameFull: Samari S
      – PersonEntity:
          Name:
            NameFull: Shahriaran F
      – PersonEntity:
          Name:
            NameFull: Yapp C
      – PersonEntity:
          Name:
            NameFull: Stanasiuk C
      – PersonEntity:
          Name:
            NameFull: Theotokis PI
      – PersonEntity:
          Name:
            NameFull: Theis FJ
      – PersonEntity:
          Name:
            NameFull: van den Bogaerdt A
      – PersonEntity:
          Name:
            NameFull: Wakimoto H
      – PersonEntity:
          Name:
            NameFull: Ware JS
      – PersonEntity:
          Name:
            NameFull: Worth CL
      – PersonEntity:
          Name:
            NameFull: Barton PJR
      – PersonEntity:
          Name:
            NameFull: Lee YA
      – PersonEntity:
          Name:
            NameFull: Teichmann SA
      – PersonEntity:
          Name:
            NameFull: Milting H
      – PersonEntity:
          Name:
            NameFull: Noseda M
      – PersonEntity:
          Name:
            NameFull: Oudit GY
      – PersonEntity:
          Name:
            NameFull: Heinig M
      – PersonEntity:
          Name:
            NameFull: Seidman JG
      – PersonEntity:
          Name:
            NameFull: Hubner N
      – PersonEntity:
          Name:
            NameFull: Seidman CE
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 05
              M: 08
              Text: 2022 Aug 05
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
          Numbering:
            – Type: volume
              Value: 377
            – Type: issue
              Value: 6606
          Titles:
            – TitleFull: Science (New York, N.Y.)
              Type: main
ResultId 1