Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
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| Title: | Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. |
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| Authors: | Reichart D; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine I, University Hospital, LMU Munich, 80336 Munich, Germany., Lindberg EL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Maatz H; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany., Miranda AMA; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; British Heart Foundation Centre for Research Excellence and Centre for Regenerative Medicine, Imperial College London, London WC2R 2LS, UK., Viveiros A; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Shvetsov N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Gärtner A; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany., Nadelmann ER; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Lee M; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Kanemaru K; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Ruiz-Orera J; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Strohmenger V; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilian University of Munich, 81377 Munich, Germany., DeLaughter DM; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Bethesda, MD 20815, USA., Patone G; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Zhang H; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Woehler A; Systems Biology Imaging Platform, Berlin Institute for Medical Systems Biology (BIMSB), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany., Lippert C; Digital Health-Machine Learning group, Hasso Plattner Institute for Digital Engineering, University of Potsdam, 14482 Potsdam, Germany.; Hasso Plattner Institute for Digital Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Kim Y; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA., Adami E; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Gorham JM; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Barnett SN; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Brown K; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Buchan RJ; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK., Chowdhury RA; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Constantinou C; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Cranley J; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Felkin LE; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK., Fox H; Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany., Ghauri A; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Gummert J; Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany., Kanda M; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; Department of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan., Li R; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Mach L; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK., McDonough B; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Bethesda, MD 20815, USA., Samari S; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Shahriaran F; Computational Health Center, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany., Yapp C; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Stanasiuk C; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany., Theotokis PI; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Theis FJ; Computational Health Center, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany., van den Bogaerdt A; ETB-Bislife Foundation, 2300 AH Leiden, Netherlands., Wakimoto H; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Ware JS; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Worth CL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Barton PJR; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Lee YA; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany., Teichmann SA; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK., Milting H; Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany., Noseda M; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; British Heart Foundation Centre for Research Excellence and Centre for Regenerative Medicine, Imperial College London, London WC2R 2LS, UK., Oudit GY; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.; Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Heinig M; Computational Health Center, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany.; Department of Informatics, Technische Universitaet Muenchen (TUM), 85748 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Munich Heart Association, Partner Site Munich, 10785 Berlin, Germany., Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Hubner N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Bethesda, MD 20815, USA. |
| Source: | Science (New York, N.Y.) [Science] 2022 Aug 05; Vol. 377 (6606), pp. eabo1984. Date of Electronic Publication: 2022 Aug 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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