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Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?

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Title: Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?
Authors: Kreir M; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium. Electronic address: mkreir@its.jnj.com., Floren W; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium., Policarpo R; Neuroscience Therapeutic Area, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Belgium., De Bondt A; High Dimensional & Computational Biology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium., Van den Wyngaert I; High Dimensional & Computational Biology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium., Teisman A; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium., Gallacher DJ; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium., Lu HR; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
Source: European journal of pharmacology [Eur J Pharmacol] 2022 Sep 15; Vol. 931, pp. 175189. Date of Electronic Publication: 2022 Aug 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?
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  Data: <searchLink fieldCode="AU" term="%22Kreir+M%22">Kreir M</searchLink>; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium. Electronic address: mkreir@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Floren+W%22">Floren W</searchLink>; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Policarpo+R%22">Policarpo R</searchLink>; Neuroscience Therapeutic Area, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Bondt+A%22">De Bondt A</searchLink>; High Dimensional & Computational Biology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+den+Wyngaert+I%22">Van den Wyngaert I</searchLink>; High Dimensional & Computational Biology, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Teisman+A%22">Teisman A</searchLink>; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Gallacher+DJ%22">Gallacher DJ</searchLink>; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Lu+HR%22">Lu HR</searchLink>; Global Safety Pharmacology, Predictive & Investigative Translational Toxicology, Nonclinical Safety, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2022 Sep 15; Vol. 931, pp. 175189. <i>Date of Electronic Publication: </i>2022 Aug 18.
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