Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.
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| Title: | Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. |
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| Authors: | Young WJ; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK., Lahrouchi N; Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Isaacs A; Deptartment of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands.; Maastricht Center for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands., Duong T; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Foco L; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy., Ahmed F; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Salman R; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK., Noordam R; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Benjamins JW; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands., Haessler J; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Repetto L; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., van den Berg ME; Department of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands., Weiss S; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Baldassari AR; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA., Bartz TM; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Evans DS; California Pacific Medical Center, Research Institute, San Francisco, CA, USA., Freudling R; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Hines O; Genetics Research Centre, St George's University of London, London, UK.; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK., Isaksen JL; Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Lin H; National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Mei H; Department of Data Science, University of Mississippi Medical Center, Jackson, USA., Moscati A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics IMBEI, University Medical Center, Johannes Gutenberg University, Mainz, Germany., Nursyifa C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Qian Y; Translational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, US., Richmond A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Roselli C; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA., Ryan KA; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Tarazona-Santos E; Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/Minas Gerais, Brazil., Thériault S; Population Health Research Institute, McMaster University, Hamilton, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec, Canada., van Duijvenboden S; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Institute of Cardiovascular Sciences, University of College London, London, UK., Warren HR; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Yao J; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Raza D; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Brighton and Sussex Medical School, Brighton, UK., Aeschbacher S; Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland., Ahlberg G; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Andreasen L; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Campbell A; Usher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.; Health Data Research UK, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Catamo E; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Cocca M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA., Darbar D; Department of Medicine, University of Illinois at Chicago, Chicago, USA., De Grandi A; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy., De Luca A; Cardiothoracovascular Department, ASUGI, University of Trieste, Trieste, Italy., Ding J; Translational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, US., Ellervik C; Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.; Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Felix SB; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine; University Medicine Greifswald, Greifswald, Germany., Froguel P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Fuchsberger C; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, USA., Gögele M; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy., Graff C; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Graff M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Guo X; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology/University of Washington, Seattle, WA, USA., Huang PL; Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA., Huikuri HV; Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Ikram MA; Department of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands., Jackson RD; Center for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA., Junttila J; Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland., Kavousi M; Department of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands., Kors JA; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, NL, The Netherlands., Leal TP; Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/Minas Gerais, Brazil.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Lin HJ; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Lind L; Deptartment of Medical Sciences, Uppsala University, Uppsala, Sweden., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu S; Center for Global Cardiometabolic Health, Departments of Epidemiology, Medicine and Surgery, Brown University, Providence, USA., MacFarlane PW; Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Meitinger T; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany., Mezzavilla M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mitchell RN; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Nauck M; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nauffal V; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA., Navarro P; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Pare G; Population Health Research Institute, McMaster University, Hamilton, Canada., Patton KK; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Pelliccione G; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Pittman A; Genetics Research Centre, St George's University of London, London, UK., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Pramstaller PP; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Reiner AP; Department of Epidemiology/University of Washington, Seattle, WA, USA.; Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA., Ribeiro ALP; Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Minas Gerais, Brazil.; Cardiology Service and Telehealth Center, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Belo Horizonte, Minas Gerais, Brazil., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Risch L; Labormedizinisches zentrum Dr. Risch, Vaduz, Liechtenstein.; Faculty of Medical Sciences, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland., Schlessinger D; Laboratory of Genetics and Genomics, National Institute on Aging, National Institute of Health, Baltimore, US., Schotten U; Deptartment of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shen X; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Greater Bay Area Institute of Precision Medicine Guangzhou, Fudan University, Nansha District, Guangzhou, China., Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine, Arrhythmia Section, Vanderbilt University Medical Center, Nashville, TN, USA., Sinagra G; Cardiothoracovascular Department, ASUGI, University of Trieste, Trieste, Italy., Sinner MF; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany., Soliman EZ; Epidemiological Cardiology Research Center EPICARE, Wake Forest School of Medicine, Winston Salem, USA., Stoll M; Maastricht Center for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands.; Dept. of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, NL, The Netherlands.; Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics IMBEI, University Medical Center, Johannes Gutenberg University, Mainz, Germany., Tarasov K; Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institute of Health, Baltimore, US., Taylor KD; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Tinker A; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trompet S; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Uitterlinden A; Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Völker U; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Völzke H; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Waldenberger M; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany.; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Weng LC; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA.; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, USA., Avery CL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA., Conen D; Population Health Research Institute, McMaster University, Hamilton, Canada., Correa A; Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, USA., Cucca F; Institute of Genetic and Biomedical Rsearch, Italian National Research Council, Monserrato, Italy., Dörr M; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine; University Medicine Greifswald, Greifswald, Germany., Gharib SA; Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA., Girotto G; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Jamshidi Y; Genetics Research Centre, St George's University of London, London, UK., Järvelin MR; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Kääb S; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kanters JK; Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Lima-Costa MF; Instituto René Rachou, fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Liu Y; Department of Medicine, Duke University, Durham, NC, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lubitz SA; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Morris AP; Department of Health Data Science, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Olesen MS; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Orini M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.; Institute of Cardiovascular Sciences, University of College London, London, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Pattaro C; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy., Peters A; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology/University of Washington, Seattle, WA, USA.; Health Systems and Population Health, University of Washington, Seattle, WA, USA., Rotter JI; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Pediatrics and Human Genetics/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Stricker B; Department of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.; Department of Cardiology, Heart and Lung Division, University Medical Center Utrecht, Utrecht, The Netherlands., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ramirez J; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Institute of Cardiovascular Sciences, University of College London, London, UK., Lambiase PD; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.; Institute of Cardiovascular Sciences, University of College London, London, UK., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA., Mifsud B; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar., Newton-Cheh C; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. cnewtoncheh@mgh.harvard.edu.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. cnewtoncheh@mgh.harvard.edu., Munroe PB; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk. |
| Source: | Nature communications [Nat Commun] 2022 Sep 01; Vol. 13 (1), pp. 5144. Date of Electronic Publication: 2022 Sep 01. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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