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Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.

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Title: Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.
Authors: Baca SC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA., Singler C; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Zacharia S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA., Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA., Morova T; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada., Hach F; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada., Ding Y; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA., Schwarz T; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA., Huang CF; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada., Anderson J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Fay AP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kalita C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Genetics, Brigham & Women's Hospital, Boston, MA, USA., Groha S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA., Pomerantz MM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA., Wang V; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., Linder S; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands., Sweeney CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zwart W; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands., Lack NA; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada.; School of Medicine, Koç University, Istanbul, Turkey., Pasaniuc B; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Takeda DY; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Gusev A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. alexander_gusev@dfci.harvard.edu.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA. alexander_gusev@dfci.harvard.edu.; Division of Genetics, Brigham & Women's Hospital, Boston, MA, USA. alexander_gusev@dfci.harvard.edu., Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. mfreedman@partners.org.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA. mfreedman@partners.org.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA. mfreedman@partners.org.
Source: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1364-1375. Date of Electronic Publication: 2022 Sep 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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Broad Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Singler+C%22">Singler C</searchLink>; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zacharia+S%22">Zacharia S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Seo+JH%22">Seo JH</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morova+T%22">Morova T</searchLink>; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Hach+F%22">Hach F</searchLink>; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schwarz+T%22">Schwarz T</searchLink>; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+CF%22">Huang CF</searchLink>; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Anderson+J%22">Anderson J</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fay+AP%22">Fay AP</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kalita+C%22">Kalita C</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Genetics, Brigham & Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Groha+S%22">Groha S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pomerantz+MM%22">Pomerantz MM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+V%22">Wang V</searchLink>; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Linder+S%22">Linder S</searchLink>; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sweeney+CJ%22">Sweeney CJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zwart+W%22">Zwart W</searchLink>; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lack+NA%22">Lack NA</searchLink>; Vancouver Prostate Centre University of British Columbia, Vancouver, British Columbia, Canada.; School of Medicine, Koç University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Pasaniuc+B%22">Pasaniuc B</searchLink>; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Takeda+DY%22">Takeda DY</searchLink>; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gusev+A%22">Gusev A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. alexander_gusev@dfci.harvard.edu.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA. alexander_gusev@dfci.harvard.edu.; Division of Genetics, Brigham & Women's Hospital, Boston, MA, USA. alexander_gusev@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Freedman+ML%22">Freedman ML</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. mfreedman@partners.org.; Center for Functional Cancer Epigenetics Dana-Farber Cancer Institute, Boston, MA, USA. mfreedman@partners.org.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA. mfreedman@partners.org.
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