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Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.

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Title: Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.
Authors: Edgar RCS; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Siddiqui G; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Hjerrild K; School of Medicine, Deakin University, Geelong, Australia., Malcolm TR; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Melbourne, Australia., Vinh NB; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Webb CT; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Melbourne, Australia., Holmes C; CSIRO Australian Centre for Disease Preparedness, Geelong, Australia., MacRaild CA; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Chernih HC; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Suen WW; CSIRO Australian Centre for Disease Preparedness, Geelong, Australia., Counihan NA; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Creek DJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Scammells PJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., McGowan S; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Melbourne, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia.
Source: ELife [Elife] 2022 Sep 13; Vol. 11. Date of Electronic Publication: 2022 Sep 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.
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  Data: <searchLink fieldCode="AU" term="%22Edgar+RCS%22">Edgar RCS</searchLink>; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Siddiqui+G%22">Siddiqui G</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Hjerrild+K%22">Hjerrild K</searchLink>; School of Medicine, Deakin University, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Malcolm+TR%22">Malcolm TR</searchLink>; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Vinh+NB%22">Vinh NB</searchLink>; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Webb+CT%22">Webb CT</searchLink>; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Holmes+C%22">Holmes C</searchLink>; CSIRO Australian Centre for Disease Preparedness, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22MacRaild+CA%22">MacRaild CA</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Chernih+HC%22">Chernih HC</searchLink>; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Suen+WW%22">Suen WW</searchLink>; CSIRO Australian Centre for Disease Preparedness, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Counihan+NA%22">Counihan NA</searchLink>; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Creek+DJ%22">Creek DJ</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Scammells+PJ%22">Scammells PJ</searchLink>; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22McGowan+S%22">McGowan S</searchLink>; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22de+Koning-Ward+TF%22">de Koning-Ward TF</searchLink>; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia.
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