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Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.

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Title: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Authors: Oh CK; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Nakamura T; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Beutler N; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Zhang X; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Piña-Crespo J; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Talantova M; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Ghatak S; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Trudler D; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Carnevale LN; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., McKercher SR; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Bakowski MA; Calibr, a division of the Scripps Research Institute, La Jolla, CA, USA., Diedrich JK; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Roberts AJ; Animal Models Core, Scripps Research Institute, La Jolla, CA, USA., Woods AK; Calibr, a division of the Scripps Research Institute, La Jolla, CA, USA., Chi V; Calibr, a division of the Scripps Research Institute, La Jolla, CA, USA., Gupta AK; Calibr, a division of the Scripps Research Institute, La Jolla, CA, USA., Rosenfeld MA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Kearns FL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Casalino L; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Shaabani N; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Liu H; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Amaro RE; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Burton DR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Yates JR 3rd; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA., Becker C; EuMentis Therapeutics, Inc., Newton, MA, USA., Rogers TF; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Chatterjee AK; Calibr, a division of the Scripps Research Institute, La Jolla, CA, USA., Lipton SA; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA. slipton@scripps.edu.; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA. slipton@scripps.edu.
Source: Nature chemical biology [Nat Chem Biol] 2023 Mar; Vol. 19 (3), pp. 275-283. Date of Electronic Publication: 2022 Sep 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
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  Data: <searchLink fieldCode="AU" term="%22Oh+CK%22">Oh CK</searchLink>; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nakamura+T%22">Nakamura T</searchLink>; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Beutler+N%22">Beutler N</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Piña-Crespo+J%22">Piña-Crespo J</searchLink>; Departments of Molecular Medicine and Neuroscience, Neurodegeneration New Medicines Center, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Talantova+M%22">Talantova M</searchLink>; 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Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shaabani+N%22">Shaabani N</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Amaro+RE%22">Amaro RE</searchLink>; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yates+JR+3rd%22">Yates JR 3rd</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2023 Mar; Vol. 19 (3), pp. 275-283. <i>Date of Electronic Publication: </i>2022 Sep 29.
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