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Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.

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Title: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Authors: Sasako T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan., Umehara T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Soeda K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan., Kaneko K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Suzuki M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kobayashi N; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan., Okazaki Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tamura-Nakano M; Communal Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Chiba T; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan., Accili D; Columbia University College of Physicians & Surgeons, Department of Medicine, New York, NY, USA., Kahn CR; Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Noda T; Department of Cell Biology, Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan., Asahara H; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp.; Toranomon Hospital, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp., Ueki K; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan. uekik@ri.ncgm.go.jp.; Department of Molecular Diabetetology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. uekik@ri.ncgm.go.jp.
Source: Nature communications [Nat Commun] 2022 Oct 05; Vol. 13 (1), pp. 5655. Date of Electronic Publication: 2022 Oct 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
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  Data: <searchLink fieldCode="AU" term="%22Sasako+T%22">Sasako T</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Umehara+T%22">Umehara T</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Soeda+K%22">Soeda K</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+K%22">Kaneko K</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+M%22">Suzuki M</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+N%22">Kobayashi N</searchLink>; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Okazaki+Y%22">Okazaki Y</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tamura-Nakano+M%22">Tamura-Nakano M</searchLink>; Communal Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Chiba+T%22">Chiba T</searchLink>; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Accili+D%22">Accili D</searchLink>; Columbia University College of Physicians & Surgeons, Department of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+CR%22">Kahn CR</searchLink>; Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Noda+T%22">Noda T</searchLink>; Department of Cell Biology, Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Asahara+H%22">Asahara H</searchLink>; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamauchi+T%22">Yamauchi T</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kadowaki+T%22">Kadowaki T</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp.; Toranomon Hospital, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp.<br /><searchLink fieldCode="AU" term="%22Ueki+K%22">Ueki K</searchLink>; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan. uekik@ri.ncgm.go.jp.; Department of Molecular Diabetetology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. uekik@ri.ncgm.go.jp.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 Oct 05; Vol. 13 (1), pp. 5655. <i>Date of Electronic Publication: </i>2022 Oct 05.
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