A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.

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Title: A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Authors: Yanchus C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Drucker KL; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kollmeyer TM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Winick-Ng W; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany., Liang M; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Pawling J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., De Lorenzo SB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Ali A; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Decker PA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Kosel ML; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Panda A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Jiang L; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Browning JWL; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lowden C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Geuenich M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Hernandez JJ; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Gosio JT; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Ahmed M; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Berman J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Trcka D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Michealraj KA; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Fortin J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Carson B; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Hollingsworth EW; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jacinto S; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Mazrooei P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zhou L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Murphy DJ; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, Scotland, UK.; Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, UK., Wang L; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Abyzov A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Dennis JW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Maass PG; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Campbell K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lachance DH; Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Wrensch M; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Wiencke J; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Mak T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA.; School of Natural Sciences, University of California, Merced, CA 95343, USA., Wrana J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Taylor MD; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zadeh G; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Dirks P; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Eckel-Passow JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada., Pombo A; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany.; Institute of Biology, Humboldt University of Berlin, 10115 Berlin, Germany., Ida CM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kvon EZ; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jenkins RB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Source: Science (New York, N.Y.) [Science] 2022 Oct 07; Vol. 378 (6615), pp. 68-78. Date of Electronic Publication: 2022 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
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Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
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      – TitleFull: A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
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          Dates:
            – D: 07
              M: 10
              Text: 2022 Oct 07
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
          Numbering:
            – Type: volume
              Value: 378
            – Type: issue
              Value: 6615
          Titles:
            – TitleFull: Science (New York, N.Y.)
              Type: main
ResultId 1