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An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma.

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Title: An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma.
Authors: Goh J; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., De Mel S; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Hoppe MM; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Mohd Abdul Rashid MB; KYAN Therapeutics, Singapore 118258, Singapore., Zhang XY; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Jaynes P; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Ka Yan Ng E; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Rahmat NDB; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Jayalakshmi; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Liu CX; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Poon L; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Chan E; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Lee J; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Chee YL; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Koh LP; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore., Tan LK; Department of Laboratory Medicine, National University Hospital, Singapore 119074, Singapore., Soh TG; Department of Laboratory Medicine, National University Hospital, Singapore 119074, Singapore., Yuen YC; Department of Pharmacy, National University Health System, Singapore 119074, Singapore., Loi HY; Department of Diagnostic Imaging, National University Hospital, Singapore 119074, Singapore., Ng SB; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Goh X; Department of Otolaryngology, National University Hospital, Singapore 119074, Singapore., Eu D; Department of Otolaryngology, National University Hospital, Singapore 119074, Singapore., Loh S; Department of Diagnostic Imaging, National University Hospital, Singapore 119074, Singapore., Ng S; Department of Diagnostic Imaging, National University Hospital, Singapore 119074, Singapore., Tan D; Mount Elizabeth Novena Hospital, Singapore 329563, Singapore.; Department of Haematology, Singapore General Hospital, Singapore 169608, Singapore., Cheah DMZ; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore., Pang WL; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore., Huang D; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore., Ong SY; Department of Haematology, Singapore General Hospital, Singapore 169608, Singapore., Nagarajan C; Department of Haematology, Singapore General Hospital, Singapore 169608, Singapore., Chan JY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.; SingHealth Duke-NUS Blood Cancer Centre, Singapore 168582, Singapore., Ha JCH; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Khoo LP; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Somasundaram N; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Tang T; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Ong CK; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore.; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.; Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Lim ST; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.; SingHealth Duke-NUS Blood Cancer Centre, Singapore 168582, Singapore.; Office of Education, Duke-NUS Medical School, Singapore 169857, Singapore., Chow EK; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; N.1 Institute for Health, National University of Singapore, Singapore 117456, Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Jeyasekharan AD; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119074, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Source: Science translational medicine [Sci Transl Med] 2022 Oct 19; Vol. 14 (667), pp. eabn7824. Date of Electronic Publication: 2022 Oct 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma.
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