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MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.

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Title: MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Authors: Cheng D; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA. Electronic address: dong.cheng@bms.com., Zinker BA; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Luo Y; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Shipkova P; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., De Oliveira CH; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Krishna G; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA., Brown EA; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA., Boehm SL; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Tirucherai GS; Clinical Pharmacology, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Gu H; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Ma Z; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Chu CH; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Onorato JM; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Kopcho LM; Leads Discovery and Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Ammar R; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA., Smith J; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Devasthale P; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA., Lawrence RM; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA., Stryker SA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Dierks EA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Azzara AV; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Carayannopoulos L; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA., Charles ED; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Lentz KA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Gordon DA; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
Source: Cell metabolism [Cell Metab] 2022 Nov 01; Vol. 34 (11), pp. 1732-1748.e5.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+D%22">Cheng D</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA. Electronic address: dong.cheng@bms.com.<br /><searchLink fieldCode="AU" term="%22Zinker+BA%22">Zinker BA</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Shipkova+P%22">Shipkova P</searchLink>; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22De+Oliveira+CH%22">De Oliveira CH</searchLink>; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Krishna+G%22">Krishna G</searchLink>; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA.<br /><searchLink fieldCode="AU" term="%22Brown+EA%22">Brown EA</searchLink>; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Boehm+SL%22">Boehm SL</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Tirucherai+GS%22">Tirucherai GS</searchLink>; Clinical Pharmacology, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Gu+H%22">Gu H</searchLink>; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Z%22">Ma Z</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Chu+CH%22">Chu CH</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Onorato+JM%22">Onorato JM</searchLink>; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Kopcho+LM%22">Kopcho LM</searchLink>; Leads Discovery and Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Ammar+R%22">Ammar R</searchLink>; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Smith+J%22">Smith J</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Devasthale+P%22">Devasthale P</searchLink>; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+RM%22">Lawrence RM</searchLink>; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Stryker+SA%22">Stryker SA</searchLink>; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Dierks+EA%22">Dierks EA</searchLink>; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Azzara+AV%22">Azzara AV</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Carayannopoulos+L%22">Carayannopoulos L</searchLink>; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA.<br /><searchLink fieldCode="AU" term="%22Charles+ED%22">Charles ED</searchLink>; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Lentz+KA%22">Lentz KA</searchLink>; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.<br /><searchLink fieldCode="AU" term="%22Gordon+DA%22">Gordon DA</searchLink>; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
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        Value: 10.1016/j.cmet.2022.10.007
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              Text: 2022 Nov 01
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