MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
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| Title: | MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity. |
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| Authors: | Cheng D; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA. Electronic address: dong.cheng@bms.com., Zinker BA; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Luo Y; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Shipkova P; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., De Oliveira CH; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Krishna G; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA., Brown EA; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA., Boehm SL; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Tirucherai GS; Clinical Pharmacology, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Gu H; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Ma Z; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Chu CH; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Onorato JM; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Kopcho LM; Leads Discovery and Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Ammar R; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA., Smith J; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Devasthale P; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA., Lawrence RM; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA., Stryker SA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Dierks EA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Azzara AV; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA., Carayannopoulos L; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA., Charles ED; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA., Lentz KA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA., Gordon DA; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA. |
| Source: | Cell metabolism [Cell Metab] 2022 Nov 01; Vol. 34 (11), pp. 1732-1748.e5. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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