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Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.

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Title: Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.
Authors: Gafar F; University of Groningen, Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, -Epidemiology and -Economics, Groningen, The Netherlands f.gafar@rug.nl., Wasmann RE; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa., McIlleron HM; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.; University of Cape Town, Institute of Infectious Disease and Molecular Medicine, Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Cape Town, South Africa., Aarnoutse RE; Radboud University Medical Center, Radboud Institute of Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands., Schaaf HS; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa., Marais BJ; The Children's Hospital at Westmead, Sydney, Australia.; The University of Sydney, Sydney Institute for Infectious Diseases, Sydney, Australia., Agarwal D; Ram Manohar Lohia Institute of Medical Sciences, Department of Paediatrics, Lucknow, India., Antwi S; Komfo Anokye Teaching Hospital, Department of Child Health, Kumasi, Ghana.; Kwame Nkrumah University of Science and Technology, School of Medical Sciences, Department of Child Health, Kumasi, Ghana., Bang ND; Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam., Bekker A; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa., Bell DJ; NHS Greater Glasgow and Clyde, Infectious Diseases Unit, Glasgow, UK., Chabala C; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.; University of Zambia, School of Medicine, Department of Paediatrics, Lusaka, Zambia.; University Teaching Hospitals - Children's Hospital, Lusaka, Zambia., Choo L; University College London, Medical Research Council Clinical Trials Unit, London, UK., Davies GR; Malawi Liverpool Wellcome Clinical Research Programme, Clinical Department, Blantyre, Malawi.; University of Liverpool, Institute of Infection, Veterinary and Ecological Sciences, Liverpool, UK., Day JN; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; University of Oxford, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, Oxford, UK., Dayal R; Sarojini Naidu Medical College, Department of Pediatrics, Agra, India., Denti P; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa., Donald PR; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa., Engidawork E; Addis Ababa University, College of Health Sciences, School of Pharmacy, Department of Pharmacology and Clinical Pharmacy, Addis Ababa, Ethiopia., Garcia-Prats AJ; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.; University of Wisconsin-Madison, School of Medicine and Public Health, Department of Pediatrics, Madison, WI, USA., Gibb D; University College London, Medical Research Council Clinical Trials Unit, London, UK., Graham SM; University of Melbourne, Department of Paediatrics and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; International Union Against Tuberculosis and Lung Disease, Paris, France., Hesseling AC; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa., Heysell SK; University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, VA, USA., Idris MI; University of Alabama at Birmingham, Department of Biology, Birmingham, AL, USA., Kabra SK; All India Institute of Medical Sciences, Departments of Pediatrics, New Delhi, India., Kinikar A; Byramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India., Kumar AKH; Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India., Kwara A; University of Florida, Emerging Pathogens Institute, College of Medicine, Gainesville, FL, USA., Lodha R; All India Institute of Medical Sciences, Departments of Pediatrics, New Delhi, India., Magis-Escurra C; Radboud University Medical Center - TB Expert Centre, Nijmegen, The Netherlands., Martinez N; Instituto Nacional de Enfermedades Respiratorias y Del Ambiente, Asunción, Paraguay., Mathew BS; Christian Medical College and Hospital, Department of Pharmacology and Clinical Pharmacology, Vellore, India., Mave V; Byramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.; Johns Hopkins University, Department of Medicine and Infectious Diseases, Baltimore, MD, USA., Mduma E; Haydom Lutheran Hospital, Center for Global Health Research, Haydom, Tanzania., Mlotha-Mitole R; Queen Elizabeth Central Hospital, Department of Paediatrics, Blantyre, Malawi., Mpagama SG; Kibong'oto Infectious Diseases Hospital, Sanya Juu, Tanzania., Mukherjee A; All India Institute of Medical Sciences, Departments of Pediatrics, New Delhi, India., Nataprawira HM; Universitas Padjadjaran, Hasan Sadikin Hospital, Faculty of Medicine, Department of Child Health, Division of Paediatric Respirology, Bandung, Indonesia., Peloquin CA; University of Florida College of Pharmacy, Gainesville, FL, USA., Pouplin T; Mahidol University, Faculty of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand., Ramachandran G; Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India., Ranjalkar J; Christian Medical College and Hospital, Department of Pharmacology and Clinical Pharmacology, Vellore, India., Roy V; Maulana Azad Medical College, Department of Pharmacology, New Delhi, India., Ruslami R; Universitas Padjadjaran, Faculty of Medicine, Department of Biomedical Sciences, Division of Pharmacology and Therapy, Bandung, Indonesia., Shah I; Bai Jerbai Wadia Hospital for Children, Department of Pediatric Infectious Diseases, Pediatric TB Clinic, Mumbai, India., Singh Y; Sarojini Naidu Medical College, Department of Pediatrics, Agra, India., Sturkenboom MGG; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands., Svensson EM; Radboud University Medical Center, Radboud Institute of Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands.; Uppsala University, Department of Pharmacy, Uppsala, Sweden., Swaminathan S; Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India.; World Health Organization, Public Health Division, Geneva, Switzerland., Thatte U; Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Department of Clinical Pharmacology, Mumbai, India., Thee S; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Berlin, Germany., Thomas TA; University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, VA, USA., Tikiso T; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa., Touw DJ; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands., Turkova A; University College London, Medical Research Council Clinical Trials Unit, London, UK., Velpandian T; All India Institute of Medical Sciences, Ocular Pharmacology and Pharmacy Division, Dr R.P. Centre, New Delhi, India., Verhagen LM; Radboud University Medical Center, Radboud Center for Infectious Diseases, Laboratory of Medical Immunology, Section of Pediatric Infectious Diseases, Nijmegen, The Netherlands.; Radboud University Medical Center, Amalia Children's Hospital, Department of Paediatric Infectious Diseases and Immunology, Nijmegen, The Netherlands.; Stellenbosch University, Family Centre for Research with UBUNTU, Department of Paediatrics and Child Health, Cape Town, South Africa., Winckler JL; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa., Yang H; University of Rochester, School of Medicine and Dentistry, Department of Biostatistics and Computational Biology, Rochester, NY, USA., Yunivita V; Universitas Padjadjaran, Faculty of Medicine, Department of Biomedical Sciences, Division of Pharmacology and Therapy, Bandung, Indonesia., Taxis K; University of Groningen, Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, -Epidemiology and -Economics, Groningen, The Netherlands., Stevens J; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.; Both authors contributed equally and shared senior authorship., Alffenaar JC; The University of Sydney, Sydney Institute for Infectious Diseases, Sydney, Australia.; The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, Australia.; Westmead Hospital, Sydney, Australia.; Both authors contributed equally and shared senior authorship.
Corporate Authors: Global Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in Pharmacokinetics of Anti-TB Drugs
Source: The European respiratory journal [Eur Respir J] 2023 Mar 09; Vol. 61 (3). Date of Electronic Publication: 2023 Mar 09 (Print Publication: 2023).
Publication Type: Systematic Review; Meta-Analysis; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Gafar+F%22">Gafar F</searchLink>; University of Groningen, Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, -Epidemiology and -Economics, Groningen, The Netherlands f.gafar@rug.nl.<br /><searchLink fieldCode="AU" term="%22Wasmann+RE%22">Wasmann RE</searchLink>; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22McIlleron+HM%22">McIlleron HM</searchLink>; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.; University of Cape Town, Institute of Infectious Disease and Molecular Medicine, Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Aarnoutse+RE%22">Aarnoutse RE</searchLink>; Radboud University Medical Center, Radboud Institute of Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schaaf+HS%22">Schaaf HS</searchLink>; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Marais+BJ%22">Marais BJ</searchLink>; The Children's Hospital at Westmead, Sydney, Australia.; The University of Sydney, Sydney Institute for Infectious Diseases, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Agarwal+D%22">Agarwal D</searchLink>; Ram Manohar Lohia Institute of Medical Sciences, Department of Paediatrics, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Antwi+S%22">Antwi S</searchLink>; Komfo Anokye Teaching Hospital, Department of Child Health, Kumasi, Ghana.; Kwame Nkrumah University of Science and Technology, School of Medical Sciences, Department of Child Health, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Bang+ND%22">Bang ND</searchLink>; Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Bekker+A%22">Bekker A</searchLink>; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Bell+DJ%22">Bell DJ</searchLink>; NHS Greater Glasgow and Clyde, Infectious Diseases Unit, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Chabala+C%22">Chabala C</searchLink>; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.; University of Zambia, School of Medicine, Department of Paediatrics, Lusaka, Zambia.; University Teaching Hospitals - Children's Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Choo+L%22">Choo L</searchLink>; University College London, Medical Research Council Clinical Trials Unit, London, UK.<br /><searchLink fieldCode="AU" term="%22Davies+GR%22">Davies GR</searchLink>; Malawi Liverpool Wellcome Clinical Research Programme, Clinical Department, Blantyre, Malawi.; University of Liverpool, Institute of Infection, Veterinary and Ecological Sciences, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Day+JN%22">Day JN</searchLink>; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; University of Oxford, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dayal+R%22">Dayal R</searchLink>; Sarojini Naidu Medical College, Department of Pediatrics, Agra, India.<br /><searchLink fieldCode="AU" term="%22Denti+P%22">Denti P</searchLink>; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Donald+PR%22">Donald PR</searchLink>; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Engidawork+E%22">Engidawork E</searchLink>; Addis Ababa University, College of Health Sciences, School of Pharmacy, Department of Pharmacology and Clinical Pharmacy, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Garcia-Prats+AJ%22">Garcia-Prats AJ</searchLink>; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.; University of Wisconsin-Madison, School of Medicine and Public Health, Department of Pediatrics, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Gibb+D%22">Gibb D</searchLink>; University College London, Medical Research Council Clinical Trials Unit, London, UK.<br /><searchLink fieldCode="AU" term="%22Graham+SM%22">Graham SM</searchLink>; University of Melbourne, Department of Paediatrics and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; International Union Against Tuberculosis and Lung Disease, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hesseling+AC%22">Hesseling AC</searchLink>; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Heysell+SK%22">Heysell SK</searchLink>; University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Idris+MI%22">Idris MI</searchLink>; University of Alabama at Birmingham, Department of Biology, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kabra+SK%22">Kabra SK</searchLink>; All India Institute of Medical Sciences, Departments of Pediatrics, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Kinikar+A%22">Kinikar A</searchLink>; Byramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.<br /><searchLink fieldCode="AU" term="%22Kumar+AKH%22">Kumar AKH</searchLink>; Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India.<br /><searchLink fieldCode="AU" term="%22Kwara+A%22">Kwara A</searchLink>; University of Florida, Emerging Pathogens Institute, College of Medicine, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lodha+R%22">Lodha R</searchLink>; All India Institute of Medical Sciences, Departments of Pediatrics, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Magis-Escurra+C%22">Magis-Escurra C</searchLink>; Radboud University Medical Center - TB Expert Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Martinez+N%22">Martinez N</searchLink>; Instituto Nacional de Enfermedades Respiratorias y Del Ambiente, Asunción, Paraguay.<br /><searchLink fieldCode="AU" term="%22Mathew+BS%22">Mathew BS</searchLink>; Christian Medical College and Hospital, Department of Pharmacology and Clinical Pharmacology, Vellore, India.<br /><searchLink fieldCode="AU" term="%22Mave+V%22">Mave V</searchLink>; Byramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.; Johns Hopkins University, Department of Medicine and Infectious Diseases, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mduma+E%22">Mduma E</searchLink>; Haydom Lutheran Hospital, Center for Global Health Research, Haydom, Tanzania.<br /><searchLink fieldCode="AU" term="%22Mlotha-Mitole+R%22">Mlotha-Mitole R</searchLink>; Queen Elizabeth Central Hospital, Department of Paediatrics, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Mpagama+SG%22">Mpagama SG</searchLink>; Kibong'oto Infectious Diseases Hospital, Sanya Juu, Tanzania.<br /><searchLink fieldCode="AU" term="%22Mukherjee+A%22">Mukherjee A</searchLink>; All India Institute of Medical Sciences, Departments of Pediatrics, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Nataprawira+HM%22">Nataprawira HM</searchLink>; Universitas Padjadjaran, Hasan Sadikin Hospital, Faculty of Medicine, Department of Child Health, Division of Paediatric Respirology, Bandung, Indonesia.<br /><searchLink fieldCode="AU" term="%22Peloquin+CA%22">Peloquin CA</searchLink>; University of Florida College of Pharmacy, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pouplin+T%22">Pouplin T</searchLink>; Mahidol University, Faculty of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Ramachandran+G%22">Ramachandran G</searchLink>; Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India.<br /><searchLink fieldCode="AU" term="%22Ranjalkar+J%22">Ranjalkar J</searchLink>; Christian Medical College and Hospital, Department of Pharmacology and Clinical Pharmacology, Vellore, India.<br /><searchLink fieldCode="AU" term="%22Roy+V%22">Roy V</searchLink>; Maulana Azad Medical College, Department of Pharmacology, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Ruslami+R%22">Ruslami R</searchLink>; Universitas Padjadjaran, Faculty of Medicine, Department of Biomedical Sciences, Division of Pharmacology and Therapy, Bandung, Indonesia.<br /><searchLink fieldCode="AU" term="%22Shah+I%22">Shah I</searchLink>; Bai Jerbai Wadia Hospital for Children, Department of Pediatric Infectious Diseases, Pediatric TB Clinic, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Singh+Y%22">Singh Y</searchLink>; Sarojini Naidu Medical College, Department of Pediatrics, Agra, India.<br /><searchLink fieldCode="AU" term="%22Sturkenboom+MGG%22">Sturkenboom MGG</searchLink>; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Svensson+EM%22">Svensson EM</searchLink>; Radboud University Medical Center, Radboud Institute of Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands.; Uppsala University, Department of Pharmacy, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Swaminathan+S%22">Swaminathan S</searchLink>; Indian Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India.; World Health Organization, Public Health Division, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thatte+U%22">Thatte U</searchLink>; Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Department of Clinical Pharmacology, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Thee+S%22">Thee S</searchLink>; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas+TA%22">Thomas TA</searchLink>; University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Tikiso+T%22">Tikiso T</searchLink>; University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Touw+DJ%22">Touw DJ</searchLink>; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Turkova+A%22">Turkova A</searchLink>; University College London, Medical Research Council Clinical Trials Unit, London, UK.<br /><searchLink fieldCode="AU" term="%22Velpandian+T%22">Velpandian T</searchLink>; All India Institute of Medical Sciences, Ocular Pharmacology and Pharmacy Division, Dr R.P. Centre, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Verhagen+LM%22">Verhagen LM</searchLink>; Radboud University Medical Center, Radboud Center for Infectious Diseases, Laboratory of Medical Immunology, Section of Pediatric Infectious Diseases, Nijmegen, The Netherlands.; Radboud University Medical Center, Amalia Children's Hospital, Department of Paediatric Infectious Diseases and Immunology, Nijmegen, The Netherlands.; Stellenbosch University, Family Centre for Research with UBUNTU, Department of Paediatrics and Child Health, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Winckler+JL%22">Winckler JL</searchLink>; Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu Tuberculosis Centre, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; University of Rochester, School of Medicine and Dentistry, Department of Biostatistics and Computational Biology, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yunivita+V%22">Yunivita V</searchLink>; Universitas Padjadjaran, Faculty of Medicine, Department of Biomedical Sciences, Division of Pharmacology and Therapy, Bandung, Indonesia.<br /><searchLink fieldCode="AU" term="%22Taxis+K%22">Taxis K</searchLink>; University of Groningen, Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, -Epidemiology and -Economics, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Stevens+J%22">Stevens J</searchLink>; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.; Both authors contributed equally and shared senior authorship.<br /><searchLink fieldCode="AU" term="%22Alffenaar+JC%22">Alffenaar JC</searchLink>; The University of Sydney, Sydney Institute for Infectious Diseases, Sydney, Australia.; The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, Australia.; Westmead Hospital, Sydney, Australia.; Both authors contributed equally and shared senior authorship.
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          Dates:
            – D: 09
              M: 03
              Text: 2023 Mar 09
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-electronic
              Value: 1399-3003
          Numbering:
            – Type: volume
              Value: 61
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: The European respiratory journal
              Type: main
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