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In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.

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Title: In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.
Authors: Wirth AK; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Wange L; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany., Vosberg S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Henrich KO; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany., Rausch C; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Özdemir E; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Zeller CM; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Richter D; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany., Feuchtinger T; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany., Kaller M; Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilian University (LMU), Munich, Germany., Hermeking H; Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilian University (LMU), Munich, Germany., Greif PA; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany., Senft D; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Jurinovic V; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Bahrami E; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Jayavelu AK; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center, Heidelberg, Germany., Westermann F; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Enard W; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany., Herold T; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.
Source: Leukemia [Leukemia] 2022 Dec; Vol. 36 (12), pp. 2863-2874. Date of Electronic Publication: 2022 Nov 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.
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  Data: <searchLink fieldCode="AU" term="%22Wirth+AK%22">Wirth AK</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wange+L%22">Wange L</searchLink>; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Vosberg+S%22">Vosberg S</searchLink>; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Henrich+KO%22">Henrich KO</searchLink>; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rausch+C%22">Rausch C</searchLink>; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Özdemir+E%22">Özdemir E</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zeller+CM%22">Zeller CM</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+D%22">Richter D</searchLink>; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Feuchtinger+T%22">Feuchtinger T</searchLink>; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kaller+M%22">Kaller M</searchLink>; Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilian University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hermeking+H%22">Hermeking H</searchLink>; Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilian University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Greif+PA%22">Greif PA</searchLink>; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Senft+D%22">Senft D</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jurinovic+V%22">Jurinovic V</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bahrami+E%22">Bahrami E</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jayavelu+AK%22">Jayavelu AK</searchLink>; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Westermann+F%22">Westermann F</searchLink>; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mann+M%22">Mann M</searchLink>; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Enard+W%22">Enard W</searchLink>; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Herold+T%22">Herold T</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2022 Dec; Vol. 36 (12), pp. 2863-2874. <i>Date of Electronic Publication: </i>2022 Nov 04.
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