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Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death.

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Title: Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death.
Authors: Jenkins LJ; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Luk IY; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Fairlie WD; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Lee EF; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Palmieri M; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Schoffer KL; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia., Tan T; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Ng I; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Vukelic N; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Tran S; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Tse JWT; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Nightingale R; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Alam Z; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Chionh F; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Iatropoulos G; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Ernst M; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Afshar-Sterle S; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia., Desai J; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Gibbs P; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Sieber OM; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia., Dhillon AS; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Tebbutt NC; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.; Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia., Mariadason JM; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2023 Jan 03; Vol. 22 (1), pp. 52-62.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
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  Data: Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death.
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  Data: <searchLink fieldCode="AU" term="%22Jenkins+LJ%22">Jenkins LJ</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Luk+IY%22">Luk IY</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fairlie+WD%22">Fairlie WD</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+EF%22">Lee EF</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Palmieri+M%22">Palmieri M</searchLink>; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Schoffer+KL%22">Schoffer KL</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tan+T%22">Tan T</searchLink>; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ng+I%22">Ng I</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Vukelic+N%22">Vukelic N</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tran+S%22">Tran S</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tse+JWT%22">Tse JWT</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Nightingale+R%22">Nightingale R</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Alam+Z%22">Alam Z</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chionh+F%22">Chionh F</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Iatropoulos+G%22">Iatropoulos G</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ernst+M%22">Ernst M</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Afshar-Sterle+S%22">Afshar-Sterle S</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Desai+J%22">Desai J</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gibbs+P%22">Gibbs P</searchLink>; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sieber+OM%22">Sieber OM</searchLink>; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dhillon+AS%22">Dhillon AS</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Tebbutt+NC%22">Tebbutt NC</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.; Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mariadason+JM%22">Mariadason JM</searchLink>; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.
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