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Germline variants associated with toxicity to immune checkpoint blockade.

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Title: Germline variants associated with toxicity to immune checkpoint blockade.
Authors: Groha S; Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard & MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Alaiwi SA; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Xu W; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Naranbhai V; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Nassar AH; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bakouny Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., El Zarif T; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Saliby RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Wan G; Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA., Rajeh A; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA., Adib E; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Nuzzo PV; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Internal Medicine and Medical Specialties, School of Medicine, University of Genoa, Genoa, Italy., Schmidt AL; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Labaki C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Alessi JV; Department of Internal Medicine and Medical Specialties, School of Medicine, University of Genoa, Genoa, Italy., Braun DA; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Shukla SA; Broad Institute of Harvard & MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA., Keenan TE; Broad Institute of Harvard & MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA., Van Allen E; Broad Institute of Harvard & MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA, USA., Awad MM; Department of Internal Medicine and Medical Specialties, School of Medicine, University of Genoa, Genoa, Italy., Manos M; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rahma O; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Zubiri L; Massachusetts General Hospital, Boston, MA, USA., Villani AC; Broad Institute of Harvard & MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Fairfax B; Department of Oncology, University of Oxford, Oxford, UK., Hammer C; Genentech, South San Francisco, CA, USA., Khan Z; Genentech, South San Francisco, CA, USA., Reynolds K; Harvard Medical School, Boston, MA, USA.; Division of Medical Oncology, Bartlett, Massachusetts General Hospital, Boston, MA, USA., Semenov Y; Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA., Schrag D; Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kehl KL; Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Freedman ML; Broad Institute of Harvard & MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Choueiri TK; Harvard Medical School, Boston, MA, USA.; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gusev A; Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. alexander_gusev@dfci.harvard.edu.; Broad Institute of Harvard & MIT, Cambridge, MA, USA. alexander_gusev@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. alexander_gusev@dfci.harvard.edu.; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA. alexander_gusev@dfci.harvard.edu.
Source: Nature medicine [Nat Med] 2022 Dec; Vol. 28 (12), pp. 2584-2591. Date of Electronic Publication: 2022 Dec 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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