CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy. - Tilsed CM; Principe N; Kidman J; Chin WL; Orozco Morales ML; Zemek RM; Chee J; Islam R; Fear VS; Forbes C; Aston WJ; Jansen M; et al. (Cell reports, 2022)