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Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.

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Title: Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.
Authors: Wigerblad G; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD, USA., Warner SA; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA., Ramos-Benitez MJ; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.; Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, Bethesda, MD, USA.; Ponce Health Science University and Ponce Research Institute, Department of Basic Sciences, School of Medicine, Ponce, Puerto Rico, USA., Kardava L; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA., Tian X; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Miao R; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Reger R; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Chakraborty M; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Wong S; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Kanthi Y; Laboratory of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Suffredini AF; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA., Dell'Orso S; Genomic Technology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Brooks S; Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., King C; Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA., Shlobin O; Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA., Nathan SD; Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA., Cohen J; Adventist Healthcare Shady Grove Medical Center, Rockville, MD, USA., Moir S; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA., Childs RW; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.; United States Public Health Service Commissioned Corps, Rockville, MD, USA., Kaplan MJ; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD, USA., Chertow DS; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.; United States Public Health Service Commissioned Corps, Rockville, MD, USA., Strich JR; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.; United States Public Health Service Commissioned Corps, Rockville, MD, USA.
Source: Science advances [Sci Adv] 2023 Jan 04; Vol. 9 (1), pp. eade8272. Date of Electronic Publication: 2023 Jan 04.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Wigerblad+G%22">Wigerblad G</searchLink>; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Warner+SA%22">Warner SA</searchLink>; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ramos-Benitez+MJ%22">Ramos-Benitez MJ</searchLink>; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.; Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, Bethesda, MD, USA.; Ponce Health Science University and Ponce Research Institute, Department of Basic Sciences, School of Medicine, Ponce, Puerto Rico, USA.<br /><searchLink fieldCode="AU" term="%22Kardava+L%22">Kardava L</searchLink>; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Miao+R%22">Miao R</searchLink>; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Reger+R%22">Reger R</searchLink>; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chakraborty+M%22">Chakraborty M</searchLink>; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wong+S%22">Wong S</searchLink>; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kanthi+Y%22">Kanthi Y</searchLink>; Laboratory of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Suffredini+AF%22">Suffredini AF</searchLink>; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dell'Orso+S%22">Dell'Orso S</searchLink>; Genomic Technology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brooks+S%22">Brooks S</searchLink>; Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22King+C%22">King C</searchLink>; Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.<br /><searchLink fieldCode="AU" term="%22Shlobin+O%22">Shlobin O</searchLink>; Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.<br /><searchLink fieldCode="AU" term="%22Nathan+SD%22">Nathan SD</searchLink>; Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+J%22">Cohen J</searchLink>; Adventist Healthcare Shady Grove Medical Center, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moir+S%22">Moir S</searchLink>; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Childs+RW%22">Childs RW</searchLink>; Laboratory of Transplantation Immunotherapy, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.; United States Public Health Service Commissioned Corps, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kaplan+MJ%22">Kaplan MJ</searchLink>; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chertow+DS%22">Chertow DS</searchLink>; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.; United States Public Health Service Commissioned Corps, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Strich+JR%22">Strich JR</searchLink>; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.; United States Public Health Service Commissioned Corps, Rockville, MD, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2023 Jan 04; Vol. 9 (1), pp. eade8272. <i>Date of Electronic Publication: </i>2023 Jan 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101653440 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2375-2548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223752548%22">23752548 </searchLink><i>NLM ISO Abbreviation: </i>Sci Adv <i>Subsets: </i>MEDLINE
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