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NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.

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Title: NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
Authors: Ryan EM; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Sadiku P; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Coelho P; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Watts ER; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Zhang A; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Howden AJM; Division of Cell Signalling and Immunology, University of Dundee, Dundee, United Kingdom., Sanchez-Garcia MA; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Bewley M; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom., Cole J; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom., McHugh BJ; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Vermaelen W; Metabolomics Expertise Centre, VIB-KU Leuven Centre for Cancer Biology, Leuven, Belgium., Ghesquiere B; Metabolomics Expertise Centre, VIB-KU Leuven Centre for Cancer Biology, Leuven, Belgium., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Centre for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China., Rodriguez Blanco G; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, and., Von Kriegsheim A; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, and., Sanchez Y; GlaxoSmithKline Research & Development, Collegeville, Pennsylvania., Rumsey W; GlaxoSmithKline Research & Development, Collegeville, Pennsylvania., Callahan JF; GlaxoSmithKline Research & Development, Collegeville, Pennsylvania., Cooper G; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Parkinson N; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Baillie K; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Cantrell DA; Division of Cell Signalling and Immunology, University of Dundee, Dundee, United Kingdom., McCafferty J; NHS Lothian, Respiratory Medicine, Edinburgh, United Kingdom; and., Choudhury G; NHS Lothian, Respiratory Medicine, Edinburgh, United Kingdom; and., Singh D; Division of Infection, Immunity, and Respiratory Medicine, University of Manchester, Manchester, United Kingdom., Dockrell DH; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Whyte MKB; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute., Walmsley SR; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2023 Apr 15; Vol. 207 (8), pp. 998-1011.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
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  Data: <searchLink fieldCode="AU" term="%22Ryan+EM%22">Ryan EM</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Sadiku+P%22">Sadiku P</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Coelho+P%22">Coelho P</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Watts+ER%22">Watts ER</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Howden+AJM%22">Howden AJM</searchLink>; Division of Cell Signalling and Immunology, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sanchez-Garcia+MA%22">Sanchez-Garcia MA</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Bewley+M%22">Bewley M</searchLink>; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cole+J%22">Cole J</searchLink>; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McHugh+BJ%22">McHugh BJ</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Vermaelen+W%22">Vermaelen W</searchLink>; Metabolomics Expertise Centre, VIB-KU Leuven Centre for Cancer Biology, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ghesquiere+B%22">Ghesquiere B</searchLink>; Metabolomics Expertise Centre, VIB-KU Leuven Centre for Cancer Biology, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Carmeliet+P%22">Carmeliet P</searchLink>; Laboratory of Angiogenesis and Vascular Metabolism, Centre for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Blanco+G%22">Rodriguez Blanco G</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, and.<br /><searchLink fieldCode="AU" term="%22Von+Kriegsheim+A%22">Von Kriegsheim A</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, and.<br /><searchLink fieldCode="AU" term="%22Sanchez+Y%22">Sanchez Y</searchLink>; GlaxoSmithKline Research & Development, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Rumsey+W%22">Rumsey W</searchLink>; GlaxoSmithKline Research & Development, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Callahan+JF%22">Callahan JF</searchLink>; GlaxoSmithKline Research & Development, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Cooper+G%22">Cooper G</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Parkinson+N%22">Parkinson N</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Baillie+K%22">Baillie K</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cantrell+DA%22">Cantrell DA</searchLink>; Division of Cell Signalling and Immunology, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McCafferty+J%22">McCafferty J</searchLink>; NHS Lothian, Respiratory Medicine, Edinburgh, United Kingdom; and.<br /><searchLink fieldCode="AU" term="%22Choudhury+G%22">Choudhury G</searchLink>; NHS Lothian, Respiratory Medicine, Edinburgh, United Kingdom; and.<br /><searchLink fieldCode="AU" term="%22Singh+D%22">Singh D</searchLink>; Division of Infection, Immunity, and Respiratory Medicine, University of Manchester, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dockrell+DH%22">Dockrell DH</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Whyte+MKB%22">Whyte MKB</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.<br /><searchLink fieldCode="AU" term="%22Walmsley+SR%22">Walmsley SR</searchLink>; University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute.
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