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Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors.

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Title: Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors.
Authors: Moghadasi SA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA., Heilmann E; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria., Khalil AM; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.; Department of Zoonotic Diseases, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Nnabuife C; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA., Kearns FL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA., Ye C; Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Moraes SN; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA., Costacurta F; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria., Esler MA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA., Aihara H; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA., von Laer D; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Palzkill T; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA., Amaro RE; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA., Harris RS; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Source: Science advances [Sci Adv] 2023 Mar 29; Vol. 9 (13), pp. eade8778. Date of Electronic Publication: 2023 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Moghadasi+SA%22">Moghadasi SA</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Heilmann+E%22">Heilmann E</searchLink>; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Khalil+AM%22">Khalil AM</searchLink>; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.; Department of Zoonotic Diseases, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.<br /><searchLink fieldCode="AU" term="%22Nnabuife+C%22">Nnabuife C</searchLink>; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kearns+FL%22">Kearns FL</searchLink>; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Ye+C%22">Ye C</searchLink>; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.<br /><searchLink fieldCode="AU" term="%22Moraes+SN%22">Moraes SN</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Costacurta+F%22">Costacurta F</searchLink>; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Esler+MA%22">Esler MA</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Aihara+H%22">Aihara H</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22von+Laer+D%22">von Laer D</searchLink>; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Martinez-Sobrido+L%22">Martinez-Sobrido L</searchLink>; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.<br /><searchLink fieldCode="AU" term="%22Palzkill+T%22">Palzkill T</searchLink>; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Amaro+RE%22">Amaro RE</searchLink>; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Harris+RS%22">Harris RS</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
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