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Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.

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Title: Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.
Authors: Cosentino J; Google Health AI, Palo Alto, CA, USA. jtcosentino@google.com., Behsaz B; Google Health AI, Cambridge, MA, USA., Alipanahi B; Google Health AI, Palo Alto, CA, USA., McCaw ZR; Google Health AI, Palo Alto, CA, USA., Hill D; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Schwantes-An TH; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Carroll A; Google Health AI, Palo Alto, CA, USA., Hobbs BD; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., McLean CY; Google Health AI, Cambridge, MA, USA., Hormozdiari F; Google Health AI, Cambridge, MA, USA. fhormoz@google.com.
Source: Nature genetics [Nat Genet] 2023 May; Vol. 55 (5), pp. 787-795. Date of Electronic Publication: 2023 Apr 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.
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  Data: <searchLink fieldCode="AU" term="%22Cosentino+J%22">Cosentino J</searchLink>; Google Health AI, Palo Alto, CA, USA. jtcosentino@google.com.<br /><searchLink fieldCode="AU" term="%22Behsaz+B%22">Behsaz B</searchLink>; Google Health AI, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alipanahi+B%22">Alipanahi B</searchLink>; Google Health AI, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22McCaw+ZR%22">McCaw ZR</searchLink>; Google Health AI, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hill+D%22">Hill D</searchLink>; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schwantes-An+TH%22">Schwantes-An TH</searchLink>; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Lai+D%22">Lai D</searchLink>; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+A%22">Carroll A</searchLink>; Google Health AI, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hobbs+BD%22">Hobbs BD</searchLink>; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+MH%22">Cho MH</searchLink>; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McLean+CY%22">McLean CY</searchLink>; Google Health AI, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hormozdiari+F%22">Hormozdiari F</searchLink>; Google Health AI, Cambridge, MA, USA. fhormoz@google.com.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2023 May; Vol. 55 (5), pp. 787-795. <i>Date of Electronic Publication: </i>2023 Apr 17.
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