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BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCA-mutant ovarian cancer.

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Title: BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCA-mutant ovarian cancer.
Authors: Gupta N; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Huang TT; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Nair JR; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., An D; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Zurcher G; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Lampert EJ; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.; Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA., McCoy A; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Cimino-Mathews A; Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Swisher EM; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA., Radke MR; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA., Lockwood CM; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Reichel JB; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA., Chiang CY; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Rockville, MD 20892, USA., Wilson KM; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Rockville, MD 20892, USA., Cheng KC; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Rockville, MD 20892, USA., Nousome D; Center for Cancer Research Collaborative Bioinformatics Resource, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Lee JM; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Jun 21; Vol. 15 (701), pp. eadd7872. Date of Electronic Publication: 2023 Jun 21.
Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCA-mutant ovarian cancer.
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  Data: <searchLink fieldCode="AU" term="%22Gupta+N%22">Gupta N</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Huang+TT%22">Huang TT</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Nair+JR%22">Nair JR</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22An+D%22">An D</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Zurcher+G%22">Zurcher G</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lampert+EJ%22">Lampert EJ</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.; Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22McCoy+A%22">McCoy A</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cimino-Mathews+A%22">Cimino-Mathews A</searchLink>; Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Swisher+EM%22">Swisher EM</searchLink>; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Radke+MR%22">Radke MR</searchLink>; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lockwood+CM%22">Lockwood CM</searchLink>; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Reichel+JB%22">Reichel JB</searchLink>; Brotman Baty Institute of Precision Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Chiang+CY%22">Chiang CY</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Rockville, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+KM%22">Wilson KM</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Rockville, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+KC%22">Cheng KC</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Rockville, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Nousome+D%22">Nousome D</searchLink>; Center for Cancer Research Collaborative Bioinformatics Resource, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JM%22">Lee JM</searchLink>; Women's Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2023 Jun 21; Vol. 15 (701), pp. eadd7872. <i>Date of Electronic Publication: </i>2023 Jun 21.
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