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Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.

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Title: Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
Authors: Bahrami E; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany., Schmid JP; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany., Jurinovic V; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Becker M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany., Wirth AK; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany., Ludwig R; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany., Kreissig S; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany., Duque Angel TV; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany., Amend D; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany., Hunt K; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany., Öllinger R; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, and Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, Technische Universität München, Munich, Germany., Rad R; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, and Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, Technische Universität München, Munich, Germany., Frenz JM; Proteomics and Cancer Cell Signaling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany., Solovey M; Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Chair of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany., Ziemann F; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Mann M; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany., Wichmann C; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany., Herold T; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Jayavelu AK; Proteomics and Cancer Cell Signaling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany. Irmela.Jeremias@helmholtz-munich.de.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. Irmela.Jeremias@helmholtz-munich.de.; Department of Pediatrics, Dr. Von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany. Irmela.Jeremias@helmholtz-munich.de.
Source: Molecular cancer [Mol Cancer] 2023 Jul 08; Vol. 22 (1), pp. 107. Date of Electronic Publication: 2023 Jul 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Bahrami+E%22">Bahrami E</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+JP%22">Schmid JP</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jurinovic+V%22">Jurinovic V</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+M%22">Becker M</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Wirth+AK%22">Wirth AK</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Ludwig+R%22">Ludwig R</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kreissig+S%22">Kreissig S</searchLink>; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Duque+Angel+TV%22">Duque Angel TV</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Amend+D%22">Amend D</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Hunt+K%22">Hunt K</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Öllinger+R%22">Öllinger R</searchLink>; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, and Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, and Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Frenz+JM%22">Frenz JM</searchLink>; Proteomics and Cancer Cell Signaling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Solovey+M%22">Solovey M</searchLink>; Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Chair of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ziemann+F%22">Ziemann F</searchLink>; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mann+M%22">Mann M</searchLink>; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vick+B%22">Vick B</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wichmann+C%22">Wichmann C</searchLink>; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Herold+T%22">Herold T</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jayavelu+AK%22">Jayavelu AK</searchLink>; Proteomics and Cancer Cell Signaling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany. Irmela.Jeremias@helmholtz-munich.de.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. Irmela.Jeremias@helmholtz-munich.de.; Department of Pediatrics, Dr. Von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany. Irmela.Jeremias@helmholtz-munich.de.
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  Data: <searchLink fieldCode="JN" term="%22101147698%22">Molecular cancer</searchLink> [Mol Cancer] 2023 Jul 08; Vol. 22 (1), pp. 107. <i>Date of Electronic Publication: </i>2023 Jul 08.
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