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LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.

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Title: LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Authors: Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Chen Z; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Yildiz U; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany., Freitas FP; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Vogel FCE; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Varga JP; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Organization, Heidelberg, Germany., Batani J; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Bartenhagen C; Center for Molecular Medicine Cologne (CMMC) and Department of Experimental Pediatric Oncology, University Children's Hospital, Medical Faculty, University of Cologne, Cologne, Germany., Schmitz W; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany., Büchel G; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center München (HMGU), Neuherberg, Germany., Zheng J; Institute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany., Meierjohann S; Department of Pathology, University of Würzburg, Würzburg, Germany., Girardi E; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Solgate GmbH, Klosterneuburg, Austria., Espinet E; Anatomy Unit, Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Flórez AF; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Dos Santos AF; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Aroua N; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Cheytan T; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Haenlin J; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Xavier da Silva TN; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Przybylla A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zeisberger P; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Superti-Furga G; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Eilers M; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany., Fabiano M; Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Schweizer U; Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Fischer M; Center for Molecular Medicine Cologne (CMMC) and Department of Experimental Pediatric Oncology, University Children's Hospital, Medical Faculty, University of Cologne, Cologne, Germany., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Friedmann Angeli JP; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Source: EMBO molecular medicine [EMBO Mol Med] 2023 Aug 07; Vol. 15 (8), pp. e18014. Date of Electronic Publication: 2023 Jul 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Alborzinia+H%22">Alborzinia H</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Yildiz+U%22">Yildiz U</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Freitas+FP%22">Freitas FP</searchLink>; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vogel+FCE%22">Vogel FCE</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Varga+JP%22">Varga JP</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Organization, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Batani+J%22">Batani J</searchLink>; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bartenhagen+C%22">Bartenhagen C</searchLink>; Center for Molecular Medicine Cologne (CMMC) and Department of Experimental Pediatric Oncology, University Children's Hospital, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitz+W%22">Schmitz W</searchLink>; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Büchel+G%22">Büchel G</searchLink>; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Michalke+B%22">Michalke B</searchLink>; Research Unit Analytical BioGeoChemistry, Helmholtz Center München (HMGU), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Meierjohann+S%22">Meierjohann S</searchLink>; Department of Pathology, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Girardi+E%22">Girardi E</searchLink>; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Solgate GmbH, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Espinet+E%22">Espinet E</searchLink>; Anatomy Unit, Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Flórez+AF%22">Flórez AF</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+AF%22">Dos Santos AF</searchLink>; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Aroua+N%22">Aroua N</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cheytan+T%22">Cheytan T</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Haenlin+J%22">Haenlin J</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlicker+L%22">Schlicker L</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Xavier+da+Silva+TN%22">Xavier da Silva TN</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Przybylla+A%22">Przybylla A</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeisberger+P%22">Zeisberger P</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Superti-Furga+G%22">Superti-Furga G</searchLink>; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Eilers+M%22">Eilers M</searchLink>; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Conrad+M%22">Conrad M</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fabiano+M%22">Fabiano M</searchLink>; Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schweizer+U%22">Schweizer U</searchLink>; Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+M%22">Fischer M</searchLink>; Center for Molecular Medicine Cologne (CMMC) and Department of Experimental Pediatric Oncology, University Children's Hospital, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+A%22">Schulze A</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Trumpp+A%22">Trumpp A</searchLink>; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Friedmann+Angeli+JP%22">Friedmann Angeli JP</searchLink>; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
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