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In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.

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Title: In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
Authors: De Giorgi M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Park SH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Castoreno A; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Cao M; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley A; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Saxena L; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Chuecos MA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA., Walkey CJ; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Doerfler AM; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Furgurson MN; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Ljungberg MC; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Patel KR; Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA., Hyde S; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Chickering T; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Lefebvre S; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Wassarman K; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Miller P; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Qin J; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Schlegel MK; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Zlatev I; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Li RG; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Kim J; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Martin JF; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Bissig KD; Department of Pediatrics, Alice and Y. T. Chen Center for Genetics and Genomics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA., Jadhav V; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 29. Date of Electronic Publication: 2023 Jul 29.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
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  Data: <searchLink fieldCode="AU" term="%22De+Giorgi+M%22">De Giorgi M</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; Department of Bioengineering, Rice University, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Castoreno+A%22">Castoreno A</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Cao+M%22">Cao M</searchLink>; Department of Bioengineering, Rice University, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Hurley+A%22">Hurley A</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Saxena+L%22">Saxena L</searchLink>; Department of Bioengineering, Rice University, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chuecos+MA%22">Chuecos MA</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Walkey+CJ%22">Walkey CJ</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Doerfler+AM%22">Doerfler AM</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Furgurson+MN%22">Furgurson MN</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ljungberg+MC%22">Ljungberg MC</searchLink>; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Patel+KR%22">Patel KR</searchLink>; Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Hyde+S%22">Hyde S</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Chickering+T%22">Chickering T</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Lefebvre+S%22">Lefebvre S</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Wassarman+K%22">Wassarman K</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Miller+P%22">Miller P</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Schlegel+MK%22">Schlegel MK</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Zlatev+I%22">Zlatev I</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Li+RG%22">Li RG</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Martin+JF%22">Martin JF</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Bissig+KD%22">Bissig KD</searchLink>; Department of Pediatrics, Alice and Y. T. Chen Center for Genetics and Genomics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+V%22">Jadhav V</searchLink>; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Bao+G%22">Bao G</searchLink>; Department of Bioengineering, Rice University, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lagor+WR%22">Lagor WR</searchLink>; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
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