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TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.

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Title: TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.
Authors: Wang Y; Department of Neuroscience, Genentech Inc, South San Francisco, United States., Wu T; Department of Neuroscience, Genentech Inc, South San Francisco, United States., Tsai MC; Department of Neuroscience, Genentech Inc, South San Francisco, United States., Rezzonico MG; Department of OMNI Bioinformatics, Genentech Inc, South San Francisco, United States., Abdel-Haleem AM; Computational Science & Exploratory Analytics, Roche IT, Hoffmann-La Roche Limited, Mississauga, Canada., Xie L; Department of Translational Imaging, Genentech Inc, South San Francisco, United States., Gandham VD; Department of Translational Imaging, Genentech Inc, South San Francisco, United States., Ngu H; Department of Pathology, Genentech Inc, South San Francisco, United States., Stark K; Department of Neuroscience, Genentech Inc, South San Francisco, United States., Glock C; Department of OMNI Bioinformatics, Genentech Inc, South San Francisco, United States., Xu D; Department of Immunology, Genentech Inc, South San Francisco, United States., Foreman O; Department of Pathology, Genentech Inc, South San Francisco, United States., Friedman BA; Department of OMNI Bioinformatics, Genentech Inc, South San Francisco, United States., Sheng M; Department of Neuroscience, Genentech Inc, South San Francisco, United States.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States., Hanson JE; Department of Neuroscience, Genentech Inc, South San Francisco, United States.
Source: ELife [Elife] 2023 Aug 09; Vol. 12. Date of Electronic Publication: 2023 Aug 09.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neuroscience, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Department of Neuroscience, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Tsai+MC%22">Tsai MC</searchLink>; Department of Neuroscience, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Rezzonico+MG%22">Rezzonico MG</searchLink>; Department of OMNI Bioinformatics, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Abdel-Haleem+AM%22">Abdel-Haleem AM</searchLink>; Computational Science & Exploratory Analytics, Roche IT, Hoffmann-La Roche Limited, Mississauga, Canada.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Department of Translational Imaging, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Gandham+VD%22">Gandham VD</searchLink>; Department of Translational Imaging, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Ngu+H%22">Ngu H</searchLink>; Department of Pathology, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Stark+K%22">Stark K</searchLink>; Department of Neuroscience, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Glock+C%22">Glock C</searchLink>; Department of OMNI Bioinformatics, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Department of Immunology, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Foreman+O%22">Foreman O</searchLink>; Department of Pathology, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Friedman+BA%22">Friedman BA</searchLink>; Department of OMNI Bioinformatics, Genentech Inc, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Sheng+M%22">Sheng M</searchLink>; Department of Neuroscience, Genentech Inc, South San Francisco, United States.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.<br /><searchLink fieldCode="AU" term="%22Hanson+JE%22">Hanson JE</searchLink>; Department of Neuroscience, Genentech Inc, South San Francisco, United States.
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