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Screening in serum-derived medium reveals differential response to compounds targeting metabolism.

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Title: Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Authors: Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ali A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Casalena D; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Do BT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA., Ferreira R; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kunchok T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Schmidt DR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Renner S; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Honeder SE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Wu M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chan SH; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Tseyang T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Stoltzfus AT; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA., Michel SLJ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA., Greaves D; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Hsu PP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA., Ng CW; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Zhang CJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Farsidjani A; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Kent JR; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA., Madariaga MLL; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA., Gramatikov IMT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Matheson NJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Griner LM; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Muir A; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA., Auld DS; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.
Source: Cell chemical biology [Cell Chem Biol] 2023 Sep 21; Vol. 30 (9), pp. 1156-1168.e7. Date of Electronic Publication: 2023 Sep 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Abbott+KL%22">Abbott KL</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Ali+A%22">Ali A</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Casalena+D%22">Casalena D</searchLink>; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Do+BT%22">Do BT</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+R%22">Ferreira R</searchLink>; 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Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Stoltzfus+AT%22">Stoltzfus AT</searchLink>; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.<br /><searchLink fieldCode="AU" term="%22Michel+SLJ%22">Michel SLJ</searchLink>; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.<br /><searchLink fieldCode="AU" term="%22Greaves+D%22">Greaves D</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Hsu+PP%22">Hsu PP</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA.<br /><searchLink fieldCode="AU" term="%22Ng+CW%22">Ng CW</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+CJ%22">Zhang CJ</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Farsidjani+A%22">Farsidjani A</searchLink>; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Kent+JR%22">Kent JR</searchLink>; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Madariaga+MLL%22">Madariaga MLL</searchLink>; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Gramatikov+IMT%22">Gramatikov IMT</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Matheson+NJ%22">Matheson NJ</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+CA%22">Lewis CA</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Clish+CB%22">Clish CB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Rees+MG%22">Rees MG</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Roth+JA%22">Roth JA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Griner+LM%22">Griner LM</searchLink>; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Muir+A%22">Muir A</searchLink>; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Auld+DS%22">Auld DS</searchLink>; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+MG%22">Vander Heiden MG</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. 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