Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses.

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Title: Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses.
Authors: Wilson DR; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Tzeng SY; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Rui Y; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Neshat SY; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Conge MJ; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Luly KM; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Wang E; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Firestone JL; GSK Vaccines, Rockville, MD 20850, USA., McAuliffe J; GSK Vaccines, Rockville, MD 20850, USA., Maruggi G; GSK Vaccines, Rockville, MD 20850, USA., Jalah R; GSK Vaccines, Rockville, MD 20850, USA., Johnson R; GSK Vaccines, Rockville, MD 20850, USA., Doloff JC; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Green JJ; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Departments of Chemical & Biomolecular Engineering, Materials Science & Engineering, Neurosurgery, Oncology, and Ophthalmology, Sidney Kimmel Comprehensive Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD 21231, USA.
Source: Advanced therapeutics [Adv Ther (Weinh)] 2023 May; Vol. 6 (5). Date of Electronic Publication: 2023 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 101724632 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2366-3987 (Electronic) Linking ISSN: 23663987 NLM ISO Abbreviation: Adv Ther (Weinh) Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wilson+DR%22">Wilson DR</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Tzeng+SY%22">Tzeng SY</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Rui+Y%22">Rui Y</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Neshat+SY%22">Neshat SY</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Conge+MJ%22">Conge MJ</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Luly+KM%22">Luly KM</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Firestone+JL%22">Firestone JL</searchLink>; GSK Vaccines, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22McAuliffe+J%22">McAuliffe J</searchLink>; GSK Vaccines, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Maruggi+G%22">Maruggi G</searchLink>; GSK Vaccines, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Jalah+R%22">Jalah R</searchLink>; GSK Vaccines, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; GSK Vaccines, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Doloff+JC%22">Doloff JC</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Green+JJ%22">Green JJ</searchLink>; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Departments of Chemical & Biomolecular Engineering, Materials Science & Engineering, Neurosurgery, Oncology, and Ophthalmology, Sidney Kimmel Comprehensive Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD 21231, USA.
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