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Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism.

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Title: Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism.
Authors: Loos M; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany. Electronic address: m.loos@uke.de., Klampe B; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany., Schulze T; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany., Yin X; King's British Heart Foundation Centre of Research Excellence, King's College London, London, UK., Theofilatos K; King's British Heart Foundation Centre of Research Excellence, King's College London, London, UK., Ulmer BM; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., Schulz C; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., Behrens CS; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., van Bergen TD; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Adami E; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Maatz H; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Schweizer M; Electron Microscopy Unit, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Brodesser S; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, 50931 Cologne, Germany., Skryabin BV; Transgenic animal and genetic engineering Models (TRAM), Faculty of Medicine of the Westfalian Wilhelms-University, 48149 Muenster, Germany., Rozhdestvensky TS; Transgenic animal and genetic engineering Models (TRAM), Faculty of Medicine of the Westfalian Wilhelms-University, 48149 Muenster, Germany., Bodbin S; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD Nottingham, UK., Stathopoulou K; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., Christ T; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., Denning C; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD Nottingham, UK., Hübner N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany., Mayr M; King's British Heart Foundation Centre of Research Excellence, King's College London, London, UK., Cuello F; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., Eschenhagen T; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany., Hansen A; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany. Electronic address: ar.hansen@uke.de.
Source: Stem cell reports [Stem Cell Reports] 2023 Nov 14; Vol. 18 (11), pp. 2123-2137. Date of Electronic Publication: 2023 Oct 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
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  Data: Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism.
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  Data: <searchLink fieldCode="AU" term="%22Loos+M%22">Loos M</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany. Electronic address: m.loos@uke.de.<br /><searchLink fieldCode="AU" term="%22Klampe+B%22">Klampe B</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+T%22">Schulze T</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; King's British Heart Foundation Centre of Research Excellence, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Theofilatos+K%22">Theofilatos K</searchLink>; King's British Heart Foundation Centre of Research Excellence, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ulmer+BM%22">Ulmer BM</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz+C%22">Schulz C</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Behrens+CS%22">Behrens CS</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22van+Bergen+TD%22">van Bergen TD</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Adami+E%22">Adami E</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Maatz+H%22">Maatz H</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schweizer+M%22">Schweizer M</searchLink>; Electron Microscopy Unit, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Brodesser+S%22">Brodesser S</searchLink>; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Skryabin+BV%22">Skryabin BV</searchLink>; Transgenic animal and genetic engineering Models (TRAM), Faculty of Medicine of the Westfalian Wilhelms-University, 48149 Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Rozhdestvensky+TS%22">Rozhdestvensky TS</searchLink>; Transgenic animal and genetic engineering Models (TRAM), Faculty of Medicine of the Westfalian Wilhelms-University, 48149 Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Bodbin+S%22">Bodbin S</searchLink>; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Stathopoulou+K%22">Stathopoulou K</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Christ+T%22">Christ T</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Denning+C%22">Denning C</searchLink>; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Hübner+N%22">Hübner N</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mayr+M%22">Mayr M</searchLink>; King's British Heart Foundation Centre of Research Excellence, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cuello+F%22">Cuello F</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Eschenhagen+T%22">Eschenhagen T</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+A%22">Hansen A</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Center for Heart Research (DZHK), Partner site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany. Electronic address: ar.hansen@uke.de.
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  Data: <searchLink fieldCode="JN" term="%22101611300%22">Stem cell reports</searchLink> [Stem Cell Reports] 2023 Nov 14; Vol. 18 (11), pp. 2123-2137. <i>Date of Electronic Publication: </i>2023 Oct 05.
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