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Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.

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Title: Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Authors: Takahashi N; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.; National Cancer Center Hospital East, Kashiwa, Japan., Hao Z; Division of Medical Oncology, University of Kentucky College of Medicine, Lexington., Villaruz LC; Division of Hematology/Oncology, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania., Zhang J; Division of Medical Oncology, University of Kansas Medical Center, Kansas City, Kansas., Ruiz J; Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina., Petty WJ; Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina., Mamdani H; Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan., Riess JW; UC Davis Comprehensive Cancer Center, Sacramento, California., Nieva J; Norris Cancer Center, University of Southern California, Los Angeles., Pachecho JM; University of Colorado Cancer Center, Aurora., Fuld AD; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Shum E; Laura and Isaac Perlmutter Cancer Center, New York, New York., Chauhan A; Division of Medical Oncology, University of Kentucky College of Medicine, Lexington., Nichols S; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Shimellis H; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., McGlone J; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Sciuto L; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Pinkiert D; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Graham C; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Shelat M; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Kattappuram R; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Abel M; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Schroeder B; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Upadhyay D; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Krishnamurthy M; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Sharma AK; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Kumar R; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Malin J; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Schultz CW; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Goyal S; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Redon CE; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Pommier Y; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Aladjem MI; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Gore SD; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Steinberg SM; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Vilimas R; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Desai P; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland., Thomas A; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.
Source: JAMA oncology [JAMA Oncol] 2023 Dec 01; Vol. 9 (12), pp. 1669-1677.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101652861 Publication Model: Print Cited Medium: Internet ISSN: 2374-2445 (Electronic) Linking ISSN: 23742437 NLM ISO Abbreviation: JAMA Oncol Subsets: MEDLINE
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  Data: Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Takahashi+N%22">Takahashi N</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.; National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Hao+Z%22">Hao Z</searchLink>; Division of Medical Oncology, University of Kentucky College of Medicine, Lexington.<br /><searchLink fieldCode="AU" term="%22Villaruz+LC%22">Villaruz LC</searchLink>; Division of Hematology/Oncology, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Division of Medical Oncology, University of Kansas Medical Center, Kansas City, Kansas.<br /><searchLink fieldCode="AU" term="%22Ruiz+J%22">Ruiz J</searchLink>; Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Petty+WJ%22">Petty WJ</searchLink>; Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Mamdani+H%22">Mamdani H</searchLink>; Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Riess+JW%22">Riess JW</searchLink>; UC Davis Comprehensive Cancer Center, Sacramento, California.<br /><searchLink fieldCode="AU" term="%22Nieva+J%22">Nieva J</searchLink>; Norris Cancer Center, University of Southern California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Pachecho+JM%22">Pachecho JM</searchLink>; University of Colorado Cancer Center, Aurora.<br /><searchLink fieldCode="AU" term="%22Fuld+AD%22">Fuld AD</searchLink>; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Shum+E%22">Shum E</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chauhan+A%22">Chauhan A</searchLink>; Division of Medical Oncology, University of Kentucky College of Medicine, Lexington.<br /><searchLink fieldCode="AU" term="%22Nichols+S%22">Nichols S</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Shimellis+H%22">Shimellis H</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22McGlone+J%22">McGlone J</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Sciuto+L%22">Sciuto L</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Pinkiert+D%22">Pinkiert D</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Graham+C%22">Graham C</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Shelat+M%22">Shelat M</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Kattappuram+R%22">Kattappuram R</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Abel+M%22">Abel M</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Schroeder+B%22">Schroeder B</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Upadhyay+D%22">Upadhyay D</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Krishnamurthy+M%22">Krishnamurthy M</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Sharma+AK%22">Sharma AK</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Malin+J%22">Malin J</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Schultz+CW%22">Schultz CW</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Goyal+S%22">Goyal S</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Redon+CE%22">Redon CE</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Pommier+Y%22">Pommier Y</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Aladjem+MI%22">Aladjem MI</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Gore+SD%22">Gore SD</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Steinberg+SM%22">Steinberg SM</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Vilimas+R%22">Vilimas R</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Desai+P%22">Desai P</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Thomas+A%22">Thomas A</searchLink>; National Cancer Institute, Center for Cancer Research, Bethesda, Maryland.
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  Data: <searchLink fieldCode="JN" term="%22101652861%22">JAMA oncology</searchLink> [JAMA Oncol] 2023 Dec 01; Vol. 9 (12), pp. 1669-1677.
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  Data: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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