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PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.

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Title: PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Authors: Pinheiro F; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Varejão N; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Sánchez-Morales A; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Bezerra F; Molecular Neurobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135, Porto, Portugal; Departamento de Biologia Molecular, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal., Navarro S; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Velázquez-Campoy A; Department of Biochemistry and Molecular & Cellular Biology, and Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza, Zaragoza, Spain; Aragon Institute for Health Research, Zaragoza (Spain) and Biomedical Research Network Center in Hepatic and Digestive Diseases (CIBERehd), Madrid, Spain., Busqué F; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Almeida MR; Molecular Neurobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135, Porto, Portugal; Departamento de Biologia Molecular, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal., Alibés R; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Reverter D; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain., Pallarès I; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain. Electronic address: irantzu.pallares@uab.cat., Ventura S; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain; ICREA, Passeig Lluis Companys 23, E-08010, Barcelona, Spain. Electronic address: salvador.ventura@uab.cat.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115837. Date of Electronic Publication: 2023 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
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  Data: <searchLink fieldCode="AU" term="%22Pinheiro+F%22">Pinheiro F</searchLink>; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Varejão+N%22">Varejão N</searchLink>; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Morales+A%22">Sánchez-Morales A</searchLink>; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Bezerra+F%22">Bezerra F</searchLink>; Molecular Neurobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135, Porto, Portugal; Departamento de Biologia Molecular, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Navarro+S%22">Navarro S</searchLink>; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Velázquez-Campoy+A%22">Velázquez-Campoy A</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, and Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza, Zaragoza, Spain; Aragon Institute for Health Research, Zaragoza (Spain) and Biomedical Research Network Center in Hepatic and Digestive Diseases (CIBERehd), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Busqué+F%22">Busqué F</searchLink>; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Almeida+MR%22">Almeida MR</searchLink>; Molecular Neurobiology Group, i3S - Instituto de Investigação e Inovação em Saúde, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135, Porto, Portugal; Departamento de Biologia Molecular, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Alibés+R%22">Alibés R</searchLink>; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Reverter+D%22">Reverter D</searchLink>; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Pallarès+I%22">Pallarès I</searchLink>; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain. Electronic address: irantzu.pallares@uab.cat.<br /><searchLink fieldCode="AU" term="%22Ventura+S%22">Ventura S</searchLink>; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain; ICREA, Passeig Lluis Companys 23, E-08010, Barcelona, Spain. Electronic address: salvador.ventura@uab.cat.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115837. <i>Date of Electronic Publication: </i>2023 Oct 06.
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