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Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.

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Title: Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
Authors: Roychowdhury T; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. tanmoy63@gmail.com.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. tanmoy63@gmail.com., Klarin D; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Healthcare System, Palo Alto, CA, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Spin JM; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Rhee YH; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Deng A; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Headley CA; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Tsao NL; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Gellatly C; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Zuber V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College, Imperial College London, London, UK., Shen F; University of Michigan Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA., Hornsby WE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Laursen IH; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Verma SS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA., Locke AE; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Einarsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Dikilitas O; Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN, USA.; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic Rochester, Rochester, MN, USA.; Mayo Clinician Investigator Training Program, Mayo Clinic Rochester, Rochester, MN, USA., Pattee JW; University of Minnesota, Minneapolis, MN, USA., Judy RL; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Pauls-Verges F; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain., Nielsen JB; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Wolford BN; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Brumpton BM; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Dilmé J; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Peypoch O; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Juscafresa LC; Vascular Surgery Department, Parc de Salut Mar-Hospital del Mar, Barcelona, Spain., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Li D; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jacobsen RL; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Garcia-Barrio MT; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Rasmussen LM; Department of Clinical Biochemistry, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark., Lee R; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Handa A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Wanhainen A; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden., Mani K; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden., Lindholt JS; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark., Obel LM; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark., Strauss E; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.; Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland., Oszkinis G; Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland.; Department of Vascular and General Surgery, Institute of Medical Sciences, University of Opole, Opole, Poland., Nelson CP; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Saxby KL; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., van Herwaarden JA; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Camacho M; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain., Davis FM; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Wasikowski R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Tsoi LC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Gudjonsson JE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Eliason JL; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA., Coleman DM; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA., Henke PK; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA., Ganesh SK; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Chen YE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Guan W; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Pankratz N; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA., Pedersen OB; Department of Clinical Immunology, Zealand University Hospital-Køge, Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Tang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Hveem K; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Gudbjartsson D; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Gretarsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ferreira MA; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Baras A; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Kullo IJ; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic Rochester, Rochester, MN, USA., Ritchie MD; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Christensen AH; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Iversen KK; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Eldrup N; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Vascular Surgery, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Sillesen H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bundgaard H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Burgess S; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Chief Scientific Advisor Office, Research and Early Development, Novo Nordisk, Copenhagen, Denmark., Gallagher K; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Jones GT; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Bown MJ; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Tsao PS; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu., Damrauer SM; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.
Corporate Authors: DiscovEHR, Regeneron Genetics Center, UK Aneurysm Growth Study, DBDS Genomic Consortium, VA Million Veteran Program
Source: Nature genetics [Nat Genet] 2023 Nov; Vol. 55 (11), pp. 1831-1842. Date of Electronic Publication: 2023 Oct 16.
Publication Type: Meta-Analysis; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
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  Data: Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Roychowdhury+T%22">Roychowdhury T</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. tanmoy63@gmail.com.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. tanmoy63@gmail.com.<br /><searchLink fieldCode="AU" term="%22Klarin+D%22">Klarin D</searchLink>; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Healthcare System, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Levin+MG%22">Levin MG</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Spin+JM%22">Spin JM</searchLink>; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rhee+YH%22">Rhee YH</searchLink>; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Deng+A%22">Deng A</searchLink>; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Headley+CA%22">Headley CA</searchLink>; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tsao+NL%22">Tsao NL</searchLink>; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gellatly+C%22">Gellatly C</searchLink>; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Zuber+V%22">Zuber V</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Shen+F%22">Shen F</searchLink>; University of Michigan Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hornsby+WE%22">Hornsby WE</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Laursen+IH%22">Laursen IH</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Verma+SS%22">Verma SS</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Locke+AE%22">Locke AE</searchLink>; Regeneron Genetics Center, LLC, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Einarsson+G%22">Einarsson G</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorleifsson+G%22">Thorleifsson G</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Graham+SE%22">Graham SE</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Dikilitas+O%22">Dikilitas O</searchLink>; Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN, USA.; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic Rochester, Rochester, MN, USA.; Mayo Clinician Investigator Training Program, Mayo Clinic Rochester, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pattee+JW%22">Pattee JW</searchLink>; University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Judy+RL%22">Judy RL</searchLink>; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pauls-Verges+F%22">Pauls-Verges F</searchLink>; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nielsen+JB%22">Nielsen JB</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Wolford+BN%22">Wolford BN</searchLink>; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Brumpton+BM%22">Brumpton BM</searchLink>; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Dilmé+J%22">Dilmé J</searchLink>; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Peypoch+O%22">Peypoch O</searchLink>; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Juscafresa+LC%22">Juscafresa LC</searchLink>; Vascular Surgery Department, Parc de Salut Mar-Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Edwards+TL%22">Edwards TL</searchLink>; Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Regeneron Genetics Center, LLC, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Banasik+K%22">Banasik K</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Brunak+S%22">Brunak S</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jacobsen+RL%22">Jacobsen RL</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Garcia-Barrio+MT%22">Garcia-Barrio MT</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Rasmussen+LM%22">Rasmussen LM</searchLink>; Department of Clinical Biochemistry, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Lee+R%22">Lee R</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Handa+A%22">Handa A</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wanhainen+A%22">Wanhainen A</searchLink>; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Mani+K%22">Mani K</searchLink>; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lindholt+JS%22">Lindholt JS</searchLink>; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Obel+LM%22">Obel LM</searchLink>; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Strauss+E%22">Strauss E</searchLink>; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.; Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland.<br /><searchLink fieldCode="AU" term="%22Oszkinis+G%22">Oszkinis G</searchLink>; Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland.; Department of Vascular and General Surgery, Institute of Medical Sciences, University of Opole, Opole, Poland.<br /><searchLink fieldCode="AU" term="%22Nelson+CP%22">Nelson CP</searchLink>; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Saxby+KL%22">Saxby KL</searchLink>; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22van+Herwaarden+JA%22">van Herwaarden JA</searchLink>; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Laan+SW%22">van der Laan SW</searchLink>; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Setten+J%22">van Setten J</searchLink>; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Camacho+M%22">Camacho M</searchLink>; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Davis+FM%22">Davis FM</searchLink>; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wasikowski+R%22">Wasikowski R</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tsoi+LC%22">Tsoi LC</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gudjonsson+JE%22">Gudjonsson JE</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Eliason+JL%22">Eliason JL</searchLink>; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Coleman+DM%22">Coleman DM</searchLink>; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Henke+PK%22">Henke PK</searchLink>; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ganesh+SK%22">Ganesh SK</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YE%22">Chen YE</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Guan+W%22">Guan W</searchLink>; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pankow+JS%22">Pankow JS</searchLink>; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pankratz+N%22">Pankratz N</searchLink>; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pedersen+OB%22">Pedersen OB</searchLink>; Department of Clinical Immunology, Zealand University Hospital-Køge, Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+D%22">Gudbjartsson D</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gretarsdottir+S%22">Gretarsdottir S</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorsteinsdottir+U%22">Thorsteinsdottir U</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Holm+H%22">Holm H</searchLink>; deCODE genetics/Amgen Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; 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Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Iversen+KK%22">Iversen KK</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Eldrup+N%22">Eldrup N</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Vascular Surgery, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sillesen+H%22">Sillesen H</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bundgaard+H%22">Bundgaard H</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ullum+H%22">Ullum H</searchLink>; Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Burgess+S%22">Burgess S</searchLink>; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gill+D%22">Gill D</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Chief Scientific Advisor Office, Research and Early Development, Novo Nordisk, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gallagher+K%22">Gallagher K</searchLink>; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sabater-Lleal+M%22">Sabater-Lleal M</searchLink>; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Surakka+I%22">Surakka I</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Jones+GT%22">Jones GT</searchLink>; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Bown+MJ%22">Bown MJ</searchLink>; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Tsao+PS%22">Tsao PS</searchLink>; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Willer+CJ%22">Willer CJ</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.<br /><searchLink fieldCode="AU" term="%22Damrauer+SM%22">Damrauer SM</searchLink>; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2023 Nov; Vol. 55 (11), pp. 1831-1842. <i>Date of Electronic Publication: </i>2023 Oct 16.
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